A
Ayyakkannu Manivannan
Researcher at University of Aberdeen
Publications - 41
Citations - 2089
Ayyakkannu Manivannan is an academic researcher from University of Aberdeen. The author has contributed to research in topics: Fundus (eye) & Scanning laser ophthalmoscopy. The author has an hindex of 27, co-authored 41 publications receiving 1999 citations.
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Journal ArticleDOI
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy.
Ermelindo C. Leal,Ayyakkannu Manivannan,Ken Ichi Hosoya,Tetsuya Terasaki,José Cunha-Vaz,António F. Ambrósio,John V. Forrester +6 more
TL;DR: The results indicate that the iNOS isoform plays a predominant role in leukostasis and BRB breakdown, and the mechanism involves ICAM-1 upregulation and tight junction protein downregulation.
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Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice.
TL;DR: Perivascular and subretinal microglia are the main cells producing lipofuscin in normal aged mouse retina and are responsible for in vivo fundus AF, suggesting that Microglia may play an important role in retinal aging and age‐related retinal diseases.
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Ultra-Wide-Field Fluorescein Angiography of the Ocular Fundus
Ayyakkannu Manivannan,Jarka Plskova,Alison Farrow,Sandra Jane McKay,Peter F. Sharp,John V. Forrester +5 more
TL;DR: In this paper, the authors evaluated the clinical applicability of a novel scanning laser ophthalmoscopy imaging system for ultra-wide-field fluorescein angiography.
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Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis.
Heping Xu,Ching L. Cheng,Mei Chen,Ayyakkannu Manivannan,Laurence Cabay,Roger G. Pertwee,Angela Alice Coutts,John V. Forrester +7 more
TL;DR: The cannabinoid agonist JWH 133 has a high in vivo, anti‐inflammatory property and may exert its effect via inhibiting the activation and function of autoreactive T cells and preventing leukocyte trafficking into the inflamed tissue.
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The scanning laser ophthalmoscope--a review of its role in bioscience and medicine.
TL;DR: The scanning laser ophthalmoscope (SLO) offers the potential for retinal imaging that is complementary both to that of the fundus camera and also the newly developing technique of optical coherence tomography (OCT).