Azhar Rafiq

TL;DR: There was a 50% loss of hippocampal GABA levels associated with knockdown ofEAAC1, and newly synthesized GABA from extracellular glutamate was significantly impaired by reduction of EAAC1 expression, indicating decreased tonic inhibition.

TL;DR: The development of epileptiform discharges in response to tetanic stimulation of the Schaeffer collaterals was studied by using extracellular field potential recordings in CA1, CA3, dentate gyrus, and entorhinal cortex and intracellular recordings inCA1 neurons in rat hippocampal-parahippocampal slices, which were cut so as to maintain reciprocal connections between entorHinal cortical and hippocampus in vitro.

TL;DR: Results indicate that selective, long-lasting reduction of GABAA subunit mRNA expression and increased excitability, possibly reflecting loss of GABAergic inhibition, occur in an in vivo model of partial complex epilepsy.

TL;DR: It is suggested that altered [Ca(2+)](i) homeostatic mechanisms may underlie some aspects of the epileptic phenotype and contribute to the persistent neuroplasticity changes associated with epilepsy.

TL;DR: A novel approach that uses ConvNet for classifying brain medical images into healthy and unhealthy brain images, using the modified version of the Alex Krizhevsky network (AlexNet) deep learning architecture on magnetic resonance images as a potential tumor classification technique.