A
Azure T Makadzange
Researcher at John Radcliffe Hospital
Publications - 10
Citations - 572
Azure T Makadzange is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 4 publications receiving 524 citations. Previous affiliations of Azure T Makadzange include University of Oxford.
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Journal ArticleDOI
Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G
Mitsunori Shiroishi,Kouhei Tsumoto,Kimie Amano,Yasuo Shirakihara,Marco Colonna,Veronique M. Braud,David S.J. Allan,Azure T Makadzange,Sarah Rowland-Jones,Benjamin E. Willcox,E. Yvonne Jones,P. Anton van der Merwe,Izumi Kumagai,Katsumi Maenaka,Katsumi Maenaka +14 more
TL;DR: ILT2 and ILT4 effectively compete with CD8 for MHCI binding, raising the possibility that ILT2 modulates CD8+ T cell activation by blocking the CD8 binding as well as by recruiting inhibitory molecules through its immunoreceptor tyrosine-based inhibitory receptor motif.
Journal ArticleDOI
Characterization of an HLA-C-restricted CTL response in chronic HIV infection.
Azure T Makadzange,Geraldine M. Gillespie,Tao Dong,Peter Kiama,Job J. Bwayo,Joshua Kimani,Frank Plummer,Philippa Easterbrook,Sarah Rowland-Jones +8 more
TL;DR: This work examined the frequency, function, and phenotype of HLA‐C‐restricted CTL in ten antiretroviral therapy‐naïve Caucasian and African individuals with chronic HIV‐1 infection who carried the Hla‐Cw04 allele.
Journal ArticleDOI
Drug resistance and optimizing dolutegravir regimens for adolescents and young adults failing antiretroviral therapy.
Vinie Kouamou,Justen Manasa,David Katzenstein,Alan M McGregor,Chiratidzo E. Ndhlovu,Azure T Makadzange +5 more
TL;DR: In 1st-line failure, implementation of TLD for many adolescents and young adults on long-term ART may require additional active drug(s) and drug resistance surveillance and susceptibility scores may inform strategies for the implementation ofTLD.
Journal ArticleDOI
Identification of a novel HLA B*57 restricted cytotoxic T-lymphocyte epitope within HIV-1 rev.
Azure T Makadzange,Geraldine M. Gillespie,Joshua Kimani,Peter Kiama,Philippa Easterbrook,Job J. Bwayo,Sarah Rowland-Jones +6 more
TL;DR: The identification of a novel HLA-B*5701, B*5703 restricted epitope within HIV-1 rev, which accounted for up to 25 and 40% of the total cytotoxic T-lymphocyte responses in two patients is described.
Posted ContentDOI
Investigating Attitudes, Motivations and Key Influencers for vaccine uptake among late adopters of COVID-19 vaccination in Africa
Azure T Makadzange,Corey Lau,Janan Dietrich,Admire Hlupeni,Nellie Myburgh,Patricia Gundidza,Nyasha Elose,Sorour Madhi,Wynona Y. James,Lawrence R. Stanberry,Chiratidzo E. Ndhlovu +10 more
TL;DR: Improving vaccine coverage will need targeted communication strategies that address negative perceptions of vaccines and associated safety and effectiveness concerns as well as traditional media remains important for health communication in Africa.