Azza B. El-Remessy

TL;DR: It is indicated that increased arginase activity in diabetes contributes to vascular endothelial dysfunction by decreasing l-arginine availability to NO synthase.

TL;DR: The cellular and molecular alterations that characterize experimental models of diabetes are considered in relation to the influence of high glucose‐mediated oxidative stress on VEGF expression and on the mechanisms of V EGF's actions under hyperglycemic induction.

TL;DR: Cellular and molecular alterations seen in diabetic models are considered in the context of high glucose-mediated oxidative stress effects on VEGF expression and action and potential therapeutic strategies for preventing V EGF overexpression or blocking its pathological actions in the diabetic retina are considered.

TL;DR: The potential use of CBD as a novel topical therapy for the treatment of glaucoma is suggested and the hypothesis that glutamate causes apoptosis of retinal neurons via the excessive formation of peroxynitrite is tested.

TL;DR: In this article, the effects of a nonpsychotropic cannabinoid, cannabidiol (CBD), were examined in streptozotocin-induced diabetic rats after 1, 2, or 4 weeks and CBD treatment significantly reduced oxidative stress; decreased the levels of tumor necrosis factor-α, vascular endothelial growth factor, and intercellular adhesion molecule-1; and prevented retinal cell death and vascular hyperpermeability in the diabetic retina.