R
Robert W. Caldwell
Researcher at Georgia Regents University
Publications - 57
Citations - 3205
Robert W. Caldwell is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Arginase & Nitric oxide synthase. The author has an hindex of 26, co-authored 57 publications receiving 2833 citations. Previous affiliations of Robert W. Caldwell include Discovery Institute.
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Journal ArticleDOI
Vascular endothelial growth factor in eye disease.
TL;DR: The roles played by VEGF in the pathogenesis of retinopathy of prematurity, diabetic Retinopathy and age-related macular degeneration are described and the potential disadvantages of inhibiting VEGf will be discussed, as will the rationales for targeting other V EGF-related modulators of angiogenesis.
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Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity : Involvement of Peroxynitrite
Azza B. El-Remessy,Ibrahim E. Khalil,Suraporn Matragoon,Gamal Abou-Mohamed,Nai Jer Tsai,Penny Roon,Ruth B. Caldwell,Robert W. Caldwell,Keith Green,Gregory I. Liou +9 more
TL;DR: The potential use of CBD as a novel topical therapy for the treatment of glaucoma is suggested and the hypothesis that glutamate causes apoptosis of retinal neurons via the excessive formation of peroxynitrite is tested.
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Experimental Diabetes Causes Breakdown of the Blood-Retina Barrier by a Mechanism Involving Tyrosine Nitration and Increases in Expression of Vascular Endothelial Growth Factor and Urokinase Plasminogen Activator Receptor
Azza B. El-Remessy,M. Ali Behzadian,Gamal Abou-Mohamed,T. Franklin,Robert W. Caldwell,Ruth B. Caldwell +5 more
TL;DR: Data indicate that early diabetes causes breakdown of the BRB by a mechanism involving the action of reactive nitrogen species in promoting expression of VEGF and uPAR.
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Contraction-induced cell wounding and release of fibroblast growth factor in heart.
TL;DR: This study demonstrates that transient, survivable disruption (wounding) of the cardiac myocyte plasma membrane is a constitutive event in vivo and proposes that contraction-induced cardiac myocytes wounding releases aFGF and bFGF, which then may act as autocrine growth-promoting stimuli.
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Inhibition of NAD(P)H Oxidase Activity Blocks Vascular Endothelial Growth Factor Overexpression and Neovascularization during Ischemic Retinopathy
Mohamed Al-Shabrawey,Manuela Bartoli,Azza B. El-Remessy,D.H. Platt,Sue Matragoon,M. Ali Behzadian,Robert W. Caldwell,Ruth B. Caldwell +7 more
TL;DR: It is concluded that inhibition of NAD(P)H oxidase activity is required for hypoxia-stimulated increases in VEGF expression and retinal neovascularization and offers a new therapeutic target for the treatment of retinopathy.