B
B. Le Mauff
Researcher at French Institute of Health and Medical Research
Publications - 17
Citations - 670
B. Le Mauff is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Transplantation & Receptor. The author has an hindex of 10, co-authored 17 publications receiving 665 citations. Previous affiliations of B. Le Mauff include University of Caen Lower Normandy.
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Journal ArticleDOI
Randomized Controlled Trial of a Monoclonal Antibody against the Interleukin-2 Receptor (33B3.1) as Compared with Rabbit Antithymocyte Globulin for Prophylaxis against Rejection of Renal Allografts
J. P. Soulillou,Diego Cantarovich,B. Le Mauff,Magali Giral,N Robillard,M. Hourmant,Michel Hirn,Yannick Jacques +7 more
TL;DR: It is concluded that 33B3.1 is as effective as antithymocyte globulin in the prevention of renal-transplant rejection, and its use results in fewer infections and side effects.
Journal ArticleDOI
Prevention of rejection of kidney transplants by monoclonal antibody directed against interleukin 2
J. P. Soulillou,B. Le Mauff,Daniel Olive,Michel Delaage,P. Peyronnet,M. Hourmant,Claude Mawas,Michel Hirn,Yannick Jacques +8 more
TL;DR: The effect of 33B3.1, a rat IgG2a monoclonal antibody directed against interleukin 2 receptors on activated T lymphocytes, was studied during the first two weeks after transplantation in an attempt to prevent rejection in primary, cadaveric, kidney transplant recipients.
Journal Article
A soluble interleukin 2 receptor produced by a normal alloreactive human T cell clone binds interleukin 2 with low affinity.
TL;DR: Several alloreactive human T cell clones derived from a rejected kidney graft were found to produce in their culture supernatants soluble interleukin 2 receptors (IL-2R) upon specific antigenic challenge (irradiated B cell line from the graft's donor).
Journal ArticleDOI
High and low affinity receptors for human interleukin for DA cells/leukemia inhibitory factor on human cells. Molecular characterization and cellular distribution.
Anne Godard,Dominique Heymann,Sylvie Raher,Ignacio Anegon,Marie-Alix Peyrat,B. Le Mauff,Elisabeth Mouray,Marc Grégoire,K Virdee,J.P. Soulillou +9 more
TL;DR: Radioiodinated recombinant human interleukin DA (HILDA)/leukemia inhibitory factor (LIF) purified from conditioned medium of Chinese hamster ovary transfected cells enabled the identification of specific receptor sites on a variety of human cell types, suggesting that the 250-kDa chain could constitute the low affinity binding component whereas the association of both 250- and 120-Da subunits would form the high affinity structure.
Journal Article
Regulation of interleukin 2 receptor expression on a human cytotoxic T lymphocyte clone, synergism between alloantigenic stimulation and interleukin 2.
TL;DR: The results obtained on a monoclonal human T cell population with highly purified rec-IL 2 demonstrate that rec- IL 2 and antigen act in synergy to induce the expression of both high and low affinity membrane IL 2 receptors.