B
B.R. DasGupta
Researcher at University of Padua
Publications - 3
Citations - 774
B.R. DasGupta is an academic researcher from University of Padua. The author has contributed to research in topics: Clostridium botulinum & Neurotoxin. The author has an hindex of 3, co-authored 3 publications receiving 752 citations.
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Journal ArticleDOI
Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E.
Giampietro Schiavo,Ornella Rossetto,S Catsicas,Patrizia Polverino de Laureto,B.R. DasGupta,Fabio Benfenati,Cesare Montecucco +6 more
TL;DR: It is shown that botulinum neurotoxin serotypes A, D, and E are zinc endoproteases specific for components of the synaptic vesicle docking and fusion complex, and the proteolytic activity of these neurotoxins is inhibited by EDTA and captopril.
Journal ArticleDOI
Botulinum neurotoxins are zinc proteins.
TL;DR: In this paper, the zinc binding motif of metalloendopeptidases, HEXXH, was found to be present in botulinum neurotoxins and the conserved segment was synthesized and shown to bind [65Zn]2+.
Journal ArticleDOI
Effect of pH on the interaction of botulinum neurotoxins A, B and E with liposomes.
TL;DR: The present data are in agreement with the idea that botulinum neurotoxins enter into nerve cells from a low pH intracellular compartment.