B. Tombor

TL;DR: In this paper, the authors present a systematic comparative mathematical analysis of the metabolic networks of 43 organisms representing all three domains of life, and show that despite significant variation in their individual constituents and pathways, these metabolic networks have the same topological scaling properties and show striking similarities to the inherent organization of complex non-biological systems.

TL;DR: This analysis of metabolic networks of 43 organisms representing all three domains of life shows that, despite significant variation in their individual constituents and pathways, these metabolic networks have the same topological scaling properties and show striking similarities to the inherent organization of complex non-biological systems.

TL;DR: In this article, the authors present the first systematic comparative mathematical analysis of the metabolic networks of 43 organisms representing all three domains of life and show that, despite significant variances in their individual constituents and pathways, these metabolic networks display the same topologic scaling properties demonstrating striking similarities to the inherent organization of complex non-biological systems.

TL;DR: The analyses suggest that during the symbiotic evolution of eukaryotes, incorporation of bacterial metabolic enzymes into the proto-archaeal proteome was constrained by the host's pre-existing metabolic architecture.

TL;DR: In this paper, the authors employ multivariate analyses to evaluate the biochemical reaction pathways characterizing 43 species and find a close relationship between these domains, whereas eukaryotic metabolic enzymes are primarily of bacterial origin.