B
Bachchu Lal
Researcher at Kennedy Krieger Institute
Publications - 63
Citations - 4265
Bachchu Lal is an academic researcher from Kennedy Krieger Institute. The author has contributed to research in topics: Glioma & Hepatocyte growth factor. The author has an hindex of 31, co-authored 59 publications receiving 3694 citations. Previous affiliations of Bachchu Lal include Johns Hopkins University & Johns Hopkins University School of Medicine.
Papers
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Journal ArticleDOI
Amide proton transfer (APT) contrast for imaging of brain tumors.
Jinyuan Zhou,Jinyuan Zhou,Bachchu Lal,David A. Wilson,John Laterra,Peter C.M. van Zijl,Peter C.M. van Zijl +6 more
TL;DR: It is demonstrated that specific MR image contrast can be produced in the water signal that reflects endogenous cellular protein and peptide content in intracranial rat 9L gliosarcomas.
Journal ArticleDOI
Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides
Jinyuan Zhou,Jinyuan Zhou,Erik Tryggestad,Zhibo Wen,Zhibo Wen,Bachchu Lal,Tingting Zhou,Rachel Grossman,Silun Wang,Kun Yan,De Xue Fu,Eric C. Ford,Betty Tyler,Jaishri O. Blakeley,John Laterra,John Laterra,Peter C.M. van Zijl,Peter C.M. van Zijl +17 more
TL;DR: The amide protons that can be detected by APT provide a unique and noninvasive MRI biomarker for distinguishing viable malignancy from radiation necrosis and predicting tumor response to therapy.
Journal ArticleDOI
c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype.
Yunqing Li,Angela Li,Martin Glas,Bachchu Lal,Bachchu Lal,Mingyao Ying,Mingyao Ying,Yingying Sang,Shuli Xia,Shuli Xia,Daniel Trageser,Hugo Guerrero-Cazares,Charles G. Eberhart,Alfredo Quiñones-Hinojosa,Björn Scheffler,John Laterra,John Laterra +16 more
TL;DR: In this article, the tyrosine kinase c-Met activation was found to induce the expression of reprogramming transcription factors known to support embryonic stem cells and induce differentiated cells to form pluripotent stem (iPS) cells.
Journal ArticleDOI
In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis
Roger Abounader,Bachchu Lal,Carey Luddy,Gary Koe,Beverly L. Davidson,Eliot M. Rosen,John Laterra +6 more
TL;DR: It is demonstrated that SF/HGF and/or c‐met expression can be targeted in vivo to inhibit tumor growth and the first in vivo application of chimeric U1snRNA/ribozymes, which have numerous potential therapeutic gene‐targeting applications are demonstrated.
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Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition
Mingyao Ying,Shervin D. Wang,Yingying Sang,Peng Sun,Bachchu Lal,Bachchu Lal,C. R. Goodwin,Hugo Guerrero-Cazares,Alfredo Quiñones-Hinojosa,John Laterra,Shuli Xia,Shuli Xia +11 more
TL;DR: Mechanisms by which RA targets GBM-derived stem-like tumor-initiating cells and novel targets applicable to differentiation therapies for glioblastoma are identified.