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Betty Tyler
Researcher at Johns Hopkins University School of Medicine
Publications - 205
Citations - 9885
Betty Tyler is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glioma & Temozolomide. The author has an hindex of 47, co-authored 187 publications receiving 8265 citations. Previous affiliations of Betty Tyler include University of Nottingham & Johns Hopkins University.
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Journal ArticleDOI
Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas.
Jing Zeng,Alfred P. See,Jillian Phallen,Christopher M. Jackson,Zineb Belcaid,Jacob Ruzevick,Nicholas M. Durham,Christian F. Meyer,Timothy J. Harris,Emilia Albesiano,Gustavo Pradilla,Eric C. Ford,John Wong,Hans J. Hammers,Dimitris Mathios,Betty Tyler,Henry Brem,Phuoc T. Tran,Drew M. Pardoll,Charles G. Drake,Michael Lim +20 more
TL;DR: The combination of PD-1 blockade and localized radiation therapy results in long-term survival in mice with orthotopic brain tumors, providing strong preclinical evidence to support combination trials in patients with GBM.
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Polylactic acid (PLA) controlled delivery carriers for biomedical applications.
TL;DR: PLA's application as drug-loaded nanoparticle drug carriers, such as liposomes, polymeric nanoparticles, dendrimers, and micelles, can encapsulate otherwise toxic hydrophobic anti-tumor drugs and evade systemic toxicities.
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Multi-pulse drug delivery from a resorbable polymeric microchip device
Amy C. Richards Grayson,Amy C. Richards Grayson,Insung S. Choi,Betty Tyler,Paul P. Wang,Henry Brem,Michael J. Cima,Robert Langer +7 more
TL;DR: Biodegradable polymeric microchips were fabricated that released four pulses of radiolabelled dextran, human growth hormone or heparin in vitro that retained on average 96 ± 12% of its bioactivity.
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Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides
Jinyuan Zhou,Jinyuan Zhou,Erik Tryggestad,Zhibo Wen,Zhibo Wen,Bachchu Lal,Tingting Zhou,Rachel Grossman,Silun Wang,Kun Yan,De Xue Fu,Eric C. Ford,Betty Tyler,Jaishri O. Blakeley,John Laterra,John Laterra,Peter C.M. van Zijl,Peter C.M. van Zijl +17 more
TL;DR: The amide protons that can be detected by APT provide a unique and noninvasive MRI biomarker for distinguishing viable malignancy from radiation necrosis and predicting tumor response to therapy.
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Paclitaxel: a review of adverse toxicities and novel delivery strategies.
TL;DR: This review addresses the toxicities associated with paclitaxel treatment and describes existing and future strategies of pac litaxel administration directed at limiting these toxicities.