B
Balbir Singh
Researcher at Universiti Malaysia Sarawak
Publications - 103
Citations - 8405
Balbir Singh is an academic researcher from Universiti Malaysia Sarawak. The author has contributed to research in topics: Plasmodium knowlesi & Malaria. The author has an hindex of 40, co-authored 94 publications receiving 7184 citations. Previous affiliations of Balbir Singh include Liverpool School of Tropical Medicine & University of the Sciences.
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Journal ArticleDOI
Efficient Surveillance of Plasmodium knowlesi Genetic Subpopulations, Malaysian Borneo, 2000-2018.
Paul C. S. Divis,Ting H Hu,Khamisah Abdul Kadir,Dayang S A Mohammad,King Ching Hii,Cyrus Daneshvar,David J. Conway,Balbir Singh +7 more
TL;DR: Population genetic analysis revealed that Plasmodium knowlesi infections in Malaysian Borneo are caused by 2 divergent parasites associated with long-tailed and pig-tailed macaques, and developed a simple genotyping PCR to efficiently distinguish between and survey the 2 parasite subpopulations.
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Genome-wide mosaicism in divergence between zoonotic malaria parasite subpopulations with separate sympatric transmission cycles
Paul C. S. Divis,Paul C. S. Divis,Craig W. Duffy,Khamisah Abdul Kadir,Balbir Singh,David J. Conway,David J. Conway +6 more
TL;DR: Deep divergence of the two sympatric P. knowlesi subpopulations is indicated, with introgression likely to have occurred recently, and the recombinant mosaic types offer enhanced diversity on which selection may operate in a currently changing landscape and human environment.
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Low levels of polymorphisms and no evidence for diversifying selection on the Plasmodium knowlesi Apical Membrane Antigen 1 gene.
Bart W. Faber,Khamisah Abdul Kadir,Roberto Rodriguez-Garcia,Edmond J. Remarque,Frederick Saul,Brigitte Vulliez Le Normand,Graham A. Bentley,Clemens H. M. Kocken,Balbir Singh +8 more
TL;DR: These analyses suggest that the pkama1 gene is not under balancing selection, as observed for pfama1 and pvama1, and that the PkAMA1 protein is not a primary target for protective humoral immune responses in their reservoir macaque hosts, unlike PfAMA1 and PvAMA1 in humans.
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Parasites that cause problems in Malaysia: soil-transmitted helminths and malaria parasites
Balbir Singh,Janet Cox-Singh +1 more
TL;DR: The prevalence and distribution of soil-transmitted helminths and malaria parasites, the problems associated with parasitic infections, the control measures taken to deal with these parasites and implications for the future will be discussed.
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Crystal structure of Plasmodium knowlesi apical membrane antigen 1 and its complex with an invasion-inhibitory monoclonal antibody
Brigitte Vulliez-Le Normand,Bart W. Faber,Frederick Saul,Marjolein van der Eijk,Alan W. Thomas,Balbir Singh,Clemens H. M. Kocken,Graham A. Bentley +7 more
TL;DR: The crystal structure of Domains 1 and 2 of the PkAMA1 ectodomain and of its complex with the invasion-inhibitory monoclonal antibody R31C2 is presented, suggesting that P. knowlesi has not developed a mechanism of immune escape from the host’s humoral response to AMA1.