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Alan W. Thomas
Researcher at Biomedical Primate Research Centre
Publications - 164
Citations - 12509
Alan W. Thomas is an academic researcher from Biomedical Primate Research Centre. The author has contributed to research in topics: Plasmodium falciparum & Antigen. The author has an hindex of 59, co-authored 164 publications receiving 12039 citations. Previous affiliations of Alan W. Thomas include National Institute for Medical Research & Guy's Hospital.
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Journal ArticleDOI
A large focus of naturally acquired Plasmodium knowlesi infections in human beings
Balbir Singh,Lee Kim Sung,Asmad Matusop,Anand Radhakrishnan,Sunita S. G. Shamsul,Janet Cox-Singh,Alan W. Thomas,David J. Conway +7 more
TL;DR: In this article, the small subunit ribosomal RNA and the circumsporozoite protein genes were sequenced for eight isolates that had been microscopically identified as P knowlesi by microscopy.
Journal ArticleDOI
In-depth analysis of the membrane and cytosolic proteome of red blood cells
TL;DR: The data reveal unexpected complexity of the RBC proteome, provide a wealth of data on its composition, shed light on several open issues in RBC biology, and form a departure point for comprehensive understanding of RBC functions.
Journal ArticleDOI
The genome of the simian and human malaria parasite Plasmodium knowlesi
Arnab Pain,Ulrike Böhme,Andrew Berry,Karen Mungall,Robert D. Finn,Andrew P. Jackson,Tobias Mourier,Jaina Mistry,Erica M. Pasini,Martin Aslett,S. Balasubrammaniam,Karsten M. Borgwardt,Karen Brooks,Celine Carret,Tim Carver,Inna Cherevach,Tracey Chillingworth,Taane G. Clark,Taane G. Clark,Mary R. Galinski,Neil Hall,D. Harper,David Harris,Heidi Hauser,Al Ivens,Christoph S. Janssen,Thomas M. Keane,Natasha Larke,Stacey A. Lapp,Matthias Marti,Sharon Moule,Irmtraud M. Meyer,Douglas Ormond,Nicholas S. Peters,Mandy Sanders,S. Sanders,Tobias Sargeant,Tobias Sargeant,Mark Simmonds,Frances Smith,R. Squares,Scott Thurston,Adrian Tivey,Danielle Walker,Brian White,Eduard Zuiderwijk,Carol Churcher,Michael A. Quail,Alan F. Cowman,C. M. R. Turner,Marie-Adèle Rajandream,Clemens H. M. Kocken,Alan W. Thomas,Chris I. Newbold,Chris I. Newbold,Bart Barrell,Matthew Berriman +56 more
TL;DR: This is the first monkey malaria parasite genome to be described, and it provides an opportunity for comparison with the recently completed P. vivax genome and other sequenced Plasmodium genomes.
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Breadth and Magnitude of Antibody Responses to Multiple Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Clinical Malaria
Faith H. A. Osier,Faith H. A. Osier,Gregory Fegan,Gregory Fegan,Spencer D. Polley,Linda M. Murungi,Federica Verra,Federica Verra,Kevin K. A. Tetteh,Brett Lowe,Tabitha W. Mwangi,Peter C. Bull,Alan W. Thomas,David R. Cavanagh,Jana S. McBride,David E. Lanar,Margaret J. Mackinnon,Margaret J. Mackinnon,David J. Conway,David J. Conway,Kevin Marsh +20 more
TL;DR: It is suggested that under natural exposure, immunity to malaria may result from high titers antibodies to multiple antigenic targets and support the idea of testing combination blood-stage vaccines optimized to induce similar antibody profiles.
Journal ArticleDOI
A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites.
Olivier Silvie,Jean-François Franetich,Stéphanie Charrin,Markus S. Mueller,Anthony Siau,Myriam Bodescot,Eric Rubinstein,Laurent Hannoun,Yupin Charoenvit,Clemens H. M. Kocken,Alan W. Thomas,Geert-Jan van Gemert,Robert W. Sauerwein,Michael J. Blackman,Robin F. Anders,Gerd Pluschke,Dominique Mazier +16 more
TL;DR: Investigation of the expression and function of another microneme protein recently identified in Plasmodium falciparum sporozoites, apical membrane antigen 1 (AMA-1), finds that interfering with sporozoite proteolytic processing may constitute a valuable strategy to prevent hepatocyte infection.