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Craig W. Duffy
Researcher at University of London
Publications - 31
Citations - 937
Craig W. Duffy is an academic researcher from University of London. The author has contributed to research in topics: Population & Gene. The author has an hindex of 16, co-authored 29 publications receiving 716 citations. Previous affiliations of Craig W. Duffy include University of Liverpool & University of Glasgow.
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Journal ArticleDOI
Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres.
Thomas D. Otto,Thomas D. Otto,Ulrike Böhme,Mandy Sanders,Adam J. Reid,Ellen Bruske,Craig W. Duffy,Peter C. Bull,Richard D. Pearson,Richard D. Pearson,Abdirahman I. Abdi,Sandra Dimonte,Lindsay B. Stewart,Susana Campino,Susana Campino,Mihir Kekre,William L Hamilton,Antoine Claessens,Sarah K. Volkman,Sarah K. Volkman,Sarah K. Volkman,Daouda Ndiaye,Alfred Amambua-Ngwa,Mahamadou Diakite,Rick M. Fairhurst,David J. Conway,Matthias Franck,Chris I. Newbold,Chris I. Newbold,Matthew Berriman +29 more
TL;DR: 15 manually curated new reference genome sequences with their nearly complete subtelomeric regions and fully assembled genes are an important new resource for the malaria research community and report the overall conserved structure and pattern of important gene families and the more clearly defined subtelomersic regions.
Journal ArticleDOI
Genome-Wide Analysis of Selection on the Malaria Parasite Plasmodium falciparum in West African Populations of Differing Infection Endemicity
Victor A. Mobegi,Craig W. Duffy,Alfred Amambua-Ngwa,Kovana M. Loua,Eugene Laman,Davis Nwakanma,Bronwyn MacInnis,Harvey Aspeling-Jones,Lee G. Murray,Taane G. Clark,Dominic P. Kwiatkowski,David J. Conway,David J. Conway +12 more
TL;DR: Within-population analyses identifying loci showing evidence of recent positive directional selection and balancing selection confirm that antimalarial drugs and host immunity have been major selective agents, and identify exceptional differentiation of allele frequencies at a small number of loci.
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Admixture in Humans of Two Divergent Plasmodium knowlesi Populations Associated with Different Macaque Host Species
Paul C. S. Divis,Balbir Singh,Fread Anderios,Shamilah Hisam,Asmad Matusop,Clemens H. M. Kocken,Samuel Assefa,Craig W. Duffy,David J. Conway +8 more
TL;DR: To investigate the parasite population genetics, sensitive and species-specific microsatellite genotyping protocols were developed and applied to analysis of samples from 10 sites covering a range of >1,600 km within which most cases have occurred.
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Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi
Samuel Assefa,Caeul Lim,Mark D. Preston,Craig W. Duffy,Mridul Nair,Sabir A. Adroub,Khamisah Abdul Kadir,Jonathan M. Goldberg,Daniel E. Neafsey,Paul C. S. Divis,Paul C. S. Divis,Taane G. Clark,Manoj T. Duraisingh,Manoj T. Duraisingh,David J. Conway,David J. Conway,Arnab Pain,Arnab Pain,Arnab Pain,Balbir Singh +19 more
TL;DR: Genome sequence analysis reveals that the zoonotic malaria parasite Plasmodium knowlesi consists of three highly divergent subpopulations, including two commonly seen in sympatric human clinical infections in Malaysian Borneo and five lines maintained in laboratory rhesus macaques after isolation in the 1960s from Peninsular Malaysia and the Philippines.
Journal ArticleDOI
Checks and balances? DNA replication and the cell cycle in Plasmodium.
TL;DR: This review focusses on the unusual cell cycles of Plasmodium, which may present a rich source of novel drug targets as well as a topic of fundamental biological interest.