Showing papers by "Baljit Singh published in 2011"

Design of Molecular Imprinted Hydrogels for Controlled Release of Cisplatin: Evaluation of Network Density of Hydrogels

Abstract: In this era of new technologies, there is an ongoing interest in enhancing the efficiency of polymer-based drug delivery systems, and molecular imprinting technique has been suggested as one step in this direction. Therefore attempts have been made to design molecular imprinted polymers (MIPs) of HEMA and MAAc for the slow release of cisplatin. The characterization of network structure of hydrogels has been studied by FTIR, swelling studies, and determining the various structural parameters of hydrogel such as polymer volume fraction in the swollen state (ϕ2,s), Flory–Huggins interaction parameter (χ1), molecular weight of the polymer chain between two neighboring cross-links (Mc), cross-link density(ρ), and the corresponding mesh size (ξ) by swelling equilibrium method. Effect of the cross-linker concentration on the network parameters has been studied along with influence of the network density on drug entrapment and release of drug from the hydrogel.

Barium Ions Crosslinked Alginate and Sterculia Gum-Based Gastroretentive Floating Drug Delivery System for Use in Peptic Ulcers

Abstract: The gastro-retentive drug delivery system is required to improve the bioavailability and therapeutic efficacy of the drugs used for the diseases associated with the stomach. Both sterculia gum and alginate enhance the repair of mucosal damage in the GI tract and pantoprazole is a therapeutic agent for GI tract ulcers. Ionotropic gelation of these polysaccharides for the release of pantoprazole will develop the double potential drug delivery systems. Therefore, in the present study, an attempt has been made to synthesize a gastro-retentive floating drug delivery system by simultaneous ionotropic gelation of alginate and sterculia gum using BaCl2 as a crosslinker. The beads have been characterized by SEMs, EDAX, and FTIR analysis. The swelling of beads has been carried out as a function of pH of the swelling media. In addition, in vitro release dynamics of an anti-ulcer model drug pantoprazole from drug-loaded beads in different release media have been carried out for the evaluation of the drug release mech...

Slow release of ciprofloxacin from double potential drug delivery system

Abstract: Psyllium polysaccharide is a bulk laxative and has been used for the treatment of constipation which is responsible for the diverticulitis. Ciprofloxacin is an antibiotic used for the microorganism infested in the diverticula. Hence, the functionalization of psyllium with polyvinyl alcohol (PVA) and poly(acrylamide) [poly(AAm)] will develop the drug delivery system (DDS) with potential for dual action for the treatment of diverticulitis, that is, by treating the constipation due to laxative action of psyllium and release of ciprofloxacin from DDS in controlled manner. The optimum conditions for the synthesis of hydrogels have been obtained as 42.21 × 10−2 mol/L of AAm, 3% (w/v) of PVA, 32.43 × 10−3 mol/L of N,N′-methylenebisacrylamide (NN-MBA), 17.53 × 10−3 mol/L ammonium persulfate, and 1 g of psyllium. The characterization of the hydrogels has been carried out by SEMs, EDAX, FTIR, and swelling studies. Swelling and drug release studies have also been carried out to determine the mechanism of swelling of hydrogels and drug release from the drug loaded hydrogels. The release of the drug from the hydrogels occurred through Fickian diffusion mechanism in pH 2.2 and pH 7.4 buffer.

Applications of natural polysaccharide-based beads for slow release herbicide formulation

Abstract: This work deals with the use of polysaccharide-based beads for controlled release of the herbicide atrazine. This article discusses the release of the herbicide atrazine from neem-alginate-clay-based beads. Formulation characteristics such as entrapment efficiency, bead size, and diffusion mechanism for release of atrazine have been evaluated.

Synthesis of smart hydrogels by radiation polymerisation for use as slow drug delivery devices

Abstract: This article deals with the modification of medicinally important psyllium polysaccharide with acrylamide through radiation crosslinked polymerisation for the design of double potential hydrogels meant for slow release of insulin. Here the double potential is due to the inherent blood sugar lowering ability of psyllium and release of insulin in controlled manner from the drug loaded hydrogels. Synthesis of hydrogels and their characterisation by scanning electron micrography (SEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and swelling studies have been discussed. The release dynamics of model drug insulin from the hydrogels has been studied for the evaluation of the release mechanism. The release of the drug from the hydrogels occurred through non-Fickian diffusion mechanism. Cet article traite de la modification du psyllium polysaccharide d'une importance therapeutique avec l'acrylamide par la reticulation sous rayonnement pour la conception d'hydrogels a potentiel double pour la liberation lente de l'insuline. Ici, le potentiel double est du a la capacite inherente de baisse de la glycemie du psyllium et la liberation de l'insuline de maniere controlee des hydrogels charges de medicament. On a discute de la synthese des hydrogels et leur caracterization par MEB, FTIR, analyse thermo-gravimetrique et etudes de gonflement. La dynamique de liberation de l'insuline (medicament modele) des hydrogels a ete etudiee pour l'evaluation du mecanisme de liberation. La liberation du medicament des hydrogels s'est produite par le biais d'un mecanisme de diffusion non-Fickien.