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Barbara E. Nickel
Researcher at University of Manitoba
Publications - 38
Citations - 1338
Barbara E. Nickel is an academic researcher from University of Manitoba. The author has contributed to research in topics: Somatomammotropin & Phosphorylation. The author has an hindex of 19, co-authored 38 publications receiving 1253 citations. Previous affiliations of Barbara E. Nickel include St. Boniface General Hospital.
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Journal ArticleDOI
The role of connexins in controlling cell growth and gene expression.
Elissavet Kardami,Xitong Dang,Dumitru A. Iacobas,Barbara E. Nickel,Madhumathy Jeyaraman,Wattamon Srisakuldee,Janna Makazan,Stéphane Tanguy,David C. Spray +8 more
TL;DR: The role of protein-protein interactions in integrating connexins into multiple signal transduction pathways; phosphorylation at specific sites and reversal of growth inhibition; and the role of the carboxy-terminal regulatory domain as a signaling molecule are discussed.
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Ubiquitinated histone H2B is preferentially located in transcriptionally active chromatin.
TL;DR: Results indicate that the mono- and polyubiquitinated species of histone H2B are preferentially located in transcriptionally active chromatin regions, consistent with the hypothesis that ubiquitinated histones have a role maintaining the structure of transcriptionallyactive chromatin.
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Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes.
Bradley W. Doble,Xitong Dang,Peipei Ping,Robert R. Fandrich,Barbara E. Nickel,Yan Jin,Peter A. Cattini,Elissavet Kardami +7 more
TL;DR: It is concluded that Cx43 inhibits cardiomyocyte DNA synthesis irrespectively of cell-cell contact or coupling and gap junction-mediated communication is required in order to reverse C x43 inhibition of DNA synthesis by S262 phosphorylation.
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Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state
Wattamon Srisakuldee,Maya M. Jeyaraman,Barbara E. Nickel,Stéphane Tanguy,Zhi-Sheng Jiang,Elissavet Kardami +5 more
TL;DR: P Cx43 marks a state of enhanced resistance to ischaemia injury promoted by PKC-activating treatments such as FGF-2 administration or ischaemic PC, and likely mediates PKCepsilon-dependent cardioprotection.
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Oxidized phospholipids in Doxorubicin-induced cardiotoxicity.
Navid Koleini,Barbara E. Nickel,Andrea L. Edel,Robert R. Fandrich,Amir Ravandi,Elissavet Kardami +5 more
TL;DR: The potential role of Ox-PL in Dox-induced pathology is discussed and the notion that a better understanding of the field could point to new strategies to prevent cardiotoxicity is supported.