B
Barbara Filipek
Researcher at Jagiellonian University Medical College
Publications - 171
Citations - 2820
Barbara Filipek is an academic researcher from Jagiellonian University Medical College. The author has contributed to research in topics: Anticonvulsant & Hot plate test. The author has an hindex of 27, co-authored 169 publications receiving 2479 citations. Previous affiliations of Barbara Filipek include Jagiellonian University.
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Journal ArticleDOI
Antinociceptive Effects of Novel A2B Adenosine Receptor Antagonists
Osama M. Abo-Salem,Alaa M. Hayallah,Andras Bilkei-Gorzo,Barbara Filipek,Andreas Zimmer,Christa E. Müller +5 more
TL;DR: Coadministration of low, subeffective doses of A2B-selective antagonists with a low dose of morphine enhanced the efficacy of morphine, indicating that analgesic effects of caffeine are mediated, at least in part, by A2 B adenosine receptors.
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Development of an in-vivo active reversible butyrylcholinesterase inhibitor
Urban Košak,Boris Brus,Damijan Knez,Roman Šink,Simon Žakelj,Jurij Trontelj,Anja Pišlar,Jasna Šlenc,Martina Gobec,Marko Živin,Larisa Tratnjek,Martina Perše,Kinga Sałat,Adrian Podkowa,Barbara Filipek,Florian Nachon,Xavier Brazzolotto,Anna Więckowska,Barbara Malawska,Jure Stojan,Irena Mlinarič Raščan,Janko Kos,Nicolas Coquelle,Jacques-Philippe Colletier,Jacques-Philippe Colletier,Stanislav Gobec +25 more
TL;DR: This study provides an advanced lead compound for developing drugs for alleviating symptoms caused by cholinergic hypofunction in advanced AD and moderately crosses the blood-brain barrier and improves memory, cognitive functions and learning abilities of mice in a model of the cholinerential deficit that characterizes AD.
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The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect
Karolina Pytka,Karolina Podkowa,Anna Rapacz,Adrian Podkowa,Elżbieta Żmudzka,Adrian Olczyk,Jacek Sapa,Barbara Filipek +7 more
TL;DR: It can be unambiguously stated that serotonergic, noradrenergic and dopaminergic systems are precisely connected with pathogenesis of depression, and should be therefore considered as valuable targets in patients' treatment.
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Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice
Kinga Sałat,Barbara Filipek +1 more
TL;DR: Antagonists of TRP channels attenuate nocifensive responses of neurogenic, tonic, and neuropathic pain, but their efficacies strongly depend on the pain model used.
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Synthesis, analgesic activity and computational study of new isothiazolopyridines of Mannich base type.
TL;DR: A series of new 4-arylpiperazine derivatives of isothiazolopyridine of Mannich base type and their non-4-aryLPiperazine analogues (3 and 4) were synthesized and assayed as potential analgesic agents to find correlation between molecular structure and biological effects (toxicity, analgesic action) of discussed compounds.