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Alaa M. Hayallah
Researcher at Assiut University
Publications - 58
Citations - 1142
Alaa M. Hayallah is an academic researcher from Assiut University. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 13, co-authored 43 publications receiving 818 citations. Previous affiliations of Alaa M. Hayallah include University of Würzburg & University of Bonn.
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Journal ArticleDOI
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity
Christopher A. Jones,Naoyuki Nishiya,Naoyuki Nishiya,Nyall London,Weiquan Zhu,Lise K. Sorensen,Aubrey C. Chan,Chinten James Lim,Haoyu Chen,Haoyu Chen,Qisheng Zhang,Peter G. Schultz,Alaa M. Hayallah,Alaa M. Hayallah,Kirk R. Thomas,Michael Famulok,Kang Zhang,Kang Zhang,Mark H. Ginsberg,Dean Y. Li +19 more
TL;DR: It is demonstrated that Robo4 mediates Slit2-dependent suppression of cellular protrusive activity through direct interaction with the intracellular adaptor protein paxillin and its paralogue, Hic-5, which identifies a new therapeutic target for ameliorating diseases involving the vascular system.
Journal ArticleDOI
Antinociceptive Effects of Novel A2B Adenosine Receptor Antagonists
Osama M. Abo-Salem,Alaa M. Hayallah,Andras Bilkei-Gorzo,Barbara Filipek,Andreas Zimmer,Christa E. Müller +5 more
TL;DR: Coadministration of low, subeffective doses of A2B-selective antagonists with a low dose of morphine enhanced the efficacy of morphine, indicating that analgesic effects of caffeine are mediated, at least in part, by A2 B adenosine receptors.
Journal ArticleDOI
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.
Alaa M. Hayallah,Jesús Sandoval-Ramírez,Ulrike Reith,Ulrike Schobert,Birgit Preiss,Britta Schumacher,John W. Daly,Christa E. Müller +7 more
TL;DR: The new potent, selective, water-soluble A2B antagonists may be useful research tools for investigating A 2B receptor function.
Journal ArticleDOI
EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid molecules.
Hesham A. Abou-Zied,Bahaa G.M. Youssif,Mamdouh F.A. Mohamed,Alaa M. Hayallah,Mohamed Abdel-Aziz +4 more
TL;DR: The apoptotic effect of the most potent compounds 11 was extensively investigated and showed a marked increase in Bax level up to 29 folds, and down-regulation in Bcl2 to 0.28 fold, in comparison to the control.
Journal ArticleDOI
Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia
Andras Bilkei-Gorzo,Osama M. Abo-Salem,Osama M. Abo-Salem,Alaa M. Hayallah,Alaa M. Hayallah,Kerstin Michel,Christa E. Müller,Andreas Zimmer +7 more
TL;DR: It is demonstrated that the blockade of adenosine receptor subtypes can decrease the magnitude of inflammatory responses, and Selective A2A antagonists may be useful for the treatment of inflammatory hyperalgesia, while A2B antagonists have potential as analgesic drugs for the Treatment of inflammatory pain.