Barbara Mavroidi

TL;DR: The biphasic dose-response photodynamic effect observed for 1 and 3 may provide a strategy against prolonged and sustained photosensitivity, and curcuminoids 2 and 4 exhibited a significant dose-dependent PDT effect.

TL;DR: The data indicate that both ligands interact with CT-DNA via a combined mode of action involving both groove binding and non-classical intercalation, while in the case of the complexes covalent bond formation takes place as well.

TL;DR: It is shown that [225Ac]225Ac-Au@TADOTAGA resulted in the retardation of tumor growth after its intratumoral injection in U87MG tumor-bearing mice, even though very low activities were injected per mouse.

TL;DR: The in vitro biological evaluation of the three complexes established their cytotoxicity and ROS generating potential, and the Ga(iii)-chrysin-imidazole complex displayed the highest anticancer efficacy against all cancer cell lines with IC50 values in the low micromolar range (<1.18 μM), a result worth further investigation.

TL;DR: Two novel complex assemblies of Cu(II) with curcumin and quercetin and the ancillary aromatic chelator 2,2'-bipyridine are presented and appear to be non-toxic in the eukaryotic experimental model Saccharomyces cerevisiae and merit further investigation of their pharmacological profile.