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Bart W. Nieuwenhuijsen
Researcher at Princeton University
Publications - 12
Citations - 664
Bart W. Nieuwenhuijsen is an academic researcher from Princeton University. The author has contributed to research in topics: Gene & Oligonucleotide. The author has an hindex of 10, co-authored 12 publications receiving 635 citations. Previous affiliations of Bart W. Nieuwenhuijsen include University of Pennsylvania.
Papers
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Journal ArticleDOI
The peripheral myelin protein gene PMP-22 is contained within the Charcot-Marie-Tooth disease type 1A duplication.
Vincent Timmerman,Eva Nelis,W. Van Hui,Bart W. Nieuwenhuijsen,K.L. Chen,S. Wang,K. Ben Othman,Bryan R. Cullen,Robin J. Leach,Clemens Oliver Hanemann,P. De Jonghe,Peter Raeymaekers,G.J.B. van Ommen,J. J. Martin,Hans Werner Müller,Jeffery M. Vance,Kenneth H. Fischbeck,C. Van Broeckhoven +17 more
TL;DR: It is suggested that increased dosage of the PMP–22 gene may be the cause of CMT1A neuropathy.
Journal ArticleDOI
Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon
S. Johannes R. Rajarao,Brian J. Platt,Stacey J. Sukoff,Qian Lin,Corey N. Bender,Bart W. Nieuwenhuijsen,Robert H. Ring,Lee E. Schechter,Sharon Rosenzweig-Lipson,Chad E. Beyer +9 more
TL;DR: Novel effects of galnon in various preclinical models of anxiety and the galaninergic system as a novel therapeutic target for the treatment of anxiety-related disorders are demonstrated, indicating rodent GALR1 receptors do not mediate galnon's in vivo activity.
Journal ArticleDOI
Snapin interacts with the N-terminus of regulator of G protein signaling 7
TL;DR: The results suggest that RGS7 could play a role in synaptic vesicle exocytosis through its interaction with snapin.
Book ChapterDOI
Yeast-based screening for inhibitors of RGS proteins.
Kathleen H. Young,Yuren Wang,Corey N. Bender,Seena K. Ajit,Fernando Ramirez,Adam M. Gilbert,Bart W. Nieuwenhuijsen +6 more
TL;DR: Two yeast-based assay platforms provide robust cellular assays that result in the identification of small molecule modulators for both RGS targets and can serve both as tools with which to probe biological implications of RGS proteins and as potential starting points toward the development of novel modulators of G-protein signaling pathways.
Journal ArticleDOI
Regulator of G Protein Signaling Z1 (RGSZ1) Interacts with Gαi Subunits and Regulates Gαi-mediated Cell Signaling
Yuren Wang,Guyu Ho,Jerry J. Zhang,Bart W. Nieuwenhuijsen,Wade Edris,Pranab K. Chanda,Kathleen H. Young +6 more
TL;DR: It is suggested that RGSZ1 serves as a GTPase accelerating protein for G αi and regulates Gαi-mediated signaling, thus expanding the potential role of R GSZ1 in G protein-mediated cellular activities.