Bartlomiej Bartkowiak

TL;DR: It is demonstrated that metazoan CDK12 and CDK13 are CTD kinases, and that dCDK12 is orthologous to yeast Ctk1, and the following orthology relationships are suggested.

TL;DR: In this paper, a first-in-class CDK12 and CDK13 covalent inhibitor, THZ531, was designed to cause a loss of gene expression with concurrent loss of elongating and hyperphosphorylated RNA polymerase II.

TL;DR: In this series, INF2 mutations were responsible for 16% of all cases of autosomal dominant FSGS, with these mutations clustered in exon 4, suggesting screening for these mutations may represent a rapid, non-invasive and cost-effective method for the diagnosis of autosome dominant FS GS.

TL;DR: The discovery of hitherto unrecognized metazoan elongation phase CTD kinase activities expands the understanding of transcription and discusses the circumstances that delayed the recognition of these kinase Activities.

TL;DR: IdentifyingCDK12-associating proteins reveals a strong enrichment for RNA-processing factors suggesting that CDK12 affects RNA processing events in two distinct ways: Indirectly through generating factor-binding phospho-epitopes on the CTD of elongating RNAPII and directly through binding to specific factors.