S
Scott B. Ficarro
Researcher at Harvard University
Publications - 146
Citations - 13389
Scott B. Ficarro is an academic researcher from Harvard University. The author has contributed to research in topics: Phosphorylation & Kinase. The author has an hindex of 54, co-authored 134 publications receiving 11374 citations. Previous affiliations of Scott B. Ficarro include Genomics Institute of the Novartis Research Foundation & University of Virginia.
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Journal ArticleDOI
Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae
Scott B. Ficarro,Mark L. McCleland,P. Todd Stukenberg,Daniel J. Burke,Mark M. Ross,Jeffrey Shabanowitz,Donald F. Hunt,Forest M. White +7 more
TL;DR: In this article, a methodology was proposed to characterize most, if not all, phosphoproteins from a whole-cell lysate in a single experiment, and a total of 216 peptide sequences defining 383 sites of phosphorylation were determined.
Journal ArticleDOI
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
Nicholas Kwiatkowski,Tinghu Zhang,Peter B. Rahl,Brian J. Abraham,Jessica Reddy,Scott B. Ficarro,Anahita Dastur,Arnaud Amzallag,Sridhar Ramaswamy,Bethany Tesar,Catherine E. Jenkins,Nancy M. Hannett,Douglas W. McMillin,Takaomi Sanda,Taebo Sim,Nam Doo Kim,A. Thomas Look,Constantine S. Mitsiades,Andrew P. Weng,Jennifer R. Brown,Cyril H. Benes,Jarrod A. Marto,Richard A. Young,Nathanael S. Gray +23 more
TL;DR: The discovery and characterization of a covalent CDK7 inhibitor, THZ1, is presented, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity forCDK7.
Journal ArticleDOI
Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.
Scott B. Ficarro,Olga Chertihin,V. Anne Westbrook,Forest M. White,Friederike L. Jayes,Petr Kalab,Jarrod A. Marto,Jeffrey Shabanowitz,John C. Herr,Donald F. Hunt,Pablo E. Visconti +10 more
TL;DR: The phosphopeptide enrichment and quantification methodology coupled to MS/MS, described here for the first time, can be employed to map and compare phosphorylation sites involved in multiple cellular processes.
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
Nicholas Kwiatkowski,Tinghu Zhang,Peter B. Rahl,Brian J. Abraham,Jessica Reddy,Scott B. Ficarro,Anahita Dastur,Arnaud Amzallag,Sridhar Ramaswamy,Bethany Tesar,Catherine E. Jenkins,Nancy M. Hannett,Douglas W. McMillin,Takaomi Sanda,Taebo Sim,Nam Doo Kim,A. Thomas Look,Constantine S. Mitsiades,Andrew P. Weng,Jennifer R. Brown,Cyril H. Benes,Jarrod A. Marto,Richard A. Young,Nathanael S. Gray +23 more
TL;DR: In this article, a covalent cyclin-dependent kinase inhibitor, THZ1, was proposed to target a remote cysteine residue located outside of the canonical kinase domain.
Journal ArticleDOI
Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma.
Pilar Caro,Amar U. Kishan,Amar U. Kishan,Erik Norberg,Illana A. Stanley,Bjoern Chapuy,Scott B. Ficarro,Klaudia Polak,Daniel Tondera,John S. Gounarides,Hong Yin,Feng Zhou,Michael R. Green,Linfeng Chen,Stefano Monti,Stefano Monti,Jarrod A. Marto,Margaret A. Shipp,Nika N. Danial +18 more
TL;DR: OxPhos-DLBCL subset, which harbors the signature of genes involved in mitochondrial metabolism, is insensitive to inhibition of BCR survival signaling but is functionally undefined.