Showing papers in "Kidney International in 2012"

TL;DR: A systematic review of cohort studies evaluating long-term renal outcomes and non-renal outcomes in patients with and without AKI identifies AKI as an independent risk factor for CKD, ESRD, death, and other important non- renewable outcomes.

TL;DR: The 2012 Kidney Disease: Improving Global Outcomes Clinical Practice Guideline for Anemia in Chronic Kidney disease aims to provide guidance on diagnosis, evaluation, management and treatment for all CKD patients at risk of or with anemia.

TL;DR: Experimental data support the clinical observations and the bidirectional nature of the relationships between AKI and CKD, and consideration should be given to the integrated clinical syndrome of diminished GFR, with acute and chronic stages, where spectrum of disease state and outcome is determined by host factors.

TL;DR: The modified exosome precipitation method is a simple, fast, highly scalable, and effective alternative for the isolation of exosomes, and may facilitate the identification of exOSomal biomarkers from urine.

TL;DR: Microvesicles derived from endothelial progenitor cells protect the kidney from ischemic acute injury by delivering their RNA content, the miRNA cargo of which contributes to reprogramming hypoxic resident renal cells to a regenerative program.

TL;DR: A resolved episode of hospital-associated acute kidney injury has important implications for the longitudinal surveillance of patients without preexisting, clinically evident kidney disease.

TL;DR: A critical role of fluid-phase alternative pathway dysregulation in the pathogenesis of C3 glomerulopathies as well as in immune complex-mediated glomerular diseases is suggested.

TL;DR: Experimental and small observational studies provide evidence that AKI impairs (innate) immunity and is associated with higher infection rates, and contrary to the conventional view, recent experimental and clinical data argue against renal ischemia-reperfusion as a sine qua non condition for the development of AKI.

TL;DR: A new GFR estimating equation works well in children with CKD in a range of GFR from 15 to 75 ml/min per 1.73 m2 and is needed to establish the applicability to children of normal stature and muscle mass, and higher GFR.

TL;DR: The results establish a renoprotective role of tubular cell autophagy in acute kidney injury where it may interfere with cell killing mechanisms and establish a renal proximal tubule-specific Autophagy-related gene 7 knockout mouse model.

TL;DR: A mouse model of kidney injury is developed using the Six2-Cre-LoxP technology to selectively activate expression of the simian diphtheria toxin receptor in renal epithelia derived from the metanephric mesenchyme, substantiating a direct role for damaged tubule epithelium in the pathogenesis of CKD.

TL;DR: Necrostatin-1 reduces organ damage and renal failure, even when administered after reperfusion, resulting in a significant survival benefit in a model of lethal renal ischemia/reperfusion injury and shows the predominance of necroptosis over apoptosis in this setting.

TL;DR: A critical review of the effects of different therapeutic strategies targeting FGF23 reduction and how these might be leveraged in a future randomized trial aimed at improving outcomes in CKD is concluded.

TL;DR: Vignettes are introduced within the context of the glomerulonephritis guideline cases with specific features to illustrate the constant need for clinical judgment and how the best treatment plans should be individualized and take into account patient preference and clinical acumen, as well as the best available evidence.

TL;DR: Premature vascular aging and arterial stiffening are observed with progression of chronic kidney disease and in end-stage renal disease and this accelerated aging is associated with outward remodeling of large vessels, characterized by increased arterial radius not totally compensated for by artery wall hypertrophy.

TL;DR: High dietary total fiber intake is associated with lower risk of inflammation and mortality in kidney disease and these associations are stronger in magnitude in those with kidney disease.

TL;DR: A reduction in dietary acid decreased kidney injury in patients with moderately reduced eGFR due to hypertensive nephropathy and that with fruits and vegetables was comparable to sodium bicarbonate, andruits and vegetables appear to be an effective kidney protective adjunct to blood pressure reduction and angiotensin-converting enzyme inhibition in hypertensive and possibly other nephrostathies.

TL;DR: Alport syndrome is treatable with angiotensin-converting enzyme inhibition to delay renal failure and therapy improves life expectancy in a time-dependent manner and supports the need for early diagnosis and early nephroprotective therapy in oligosymptomatic patients.

TL;DR: Clinical and preclinical studies of AKI are summarized to summarized and growing evidence implicates renal injury as an instigator and multiplier of pulmonary, cardiac, hepatic, and neurologic dysfunction and its role in distant organ injury.

TL;DR: Observational studies as well as small trials suggest that certain serotonin-selective reuptake inhibitors may be safe to use in patients with advanced CKD and ESRD and nonpharmacologic treatments were explored in selected E SRD samples.

TL;DR: The clinical features, kidney biopsy findings, alternative pathway abnormalities, glomerular proteomic profile, and follow-up in 12 cases of C3GN are described, finding that renal function remained stable in the majority of patients with native kidney disease.

TL;DR: This review describes important shortcomings and deficiencies with the current approach and understanding of CKD in the older and elderly adult.

TL;DR: In this article, the authors studied the relationship between podocyte detachment and reduced endothelial cell fenestration and relationships between these features and the classic structural changes of diabetic nephropathy.

TL;DR: In this paper, the authors investigated the effects and possible mechanisms by which Klotho expression is regulated during uremia in uninephrectomized B-6 mice given the uremic toxins indoxyl sulfate or p -cresyl sulfates.

TL;DR: Klotho and osteopontin were upregulated by VDRA therapy in chronic kidney disease, independent of changes in serum parathyroid hormone and calcium.

TL;DR: Increased staining forPLA2R in glomeruli of renal biopsies tightly correlates with the presence of PLA2R autoantibodies in the serum and this may help discriminate between primary and secondary membranous nephropathy.

TL;DR: Treatment effects of ARB compared with non-RAASi-based therapy on renal and cardiovascular outcomes were greater in patients with type 2 diabetic nephropathy with lower than higher dietary sodium intake, which underscores the avoidance of excessive sodium Intake, particularly in type 2 diabetes patients receiving ARB therapy.