Basil Elnazir

TL;DR: Both 1,25(OH)(2)D(3) and other VDR agonists significantly reduce the pro-inflammatory response to antigen challenge in CF airway epithelial cells and have significant therapeutic potential in CF.

TL;DR: It is proposed that there is postnatal development of the ventilatory and cardiovascular responses evoked by systemic hypoxia and of the role of locally released adenosine in these responses: at 3 days,Adenosine released within the central nervous system and within the kidney is a major contributor to the secondary fall in ventilation and renal vasoconstriction respectively, whereas at 3 weeks, adenosines makes little contribution to the ventilated response.

TL;DR: The aim of this study was to assess the effect of 15 weeks of vitamin D3 supplementation compared with placebo in Irish children with asthma.

TL;DR: Vitamin D deficiency and its deficiency have a number of biological effects that are potentially important in altering the course of disease pathogenesis and severity in asthma.

TL;DR: Current evidence suggests that supplementation with moderate doses of vitamin D may be appropriate for maintenance of bone health in asthmatics, particularly steroid users, but the effect is inconsistent with preliminary evidence from different studies suggesting vitamin D is both beneficial and detrimental to asthma genesis and severity.