Basil V. Worgul

TL;DR: The findings do not support the ICRP 60 risk guideline assumption of a 5-Gy threshold for “detectable opacities” from protracted exposures but rather point to a dose–effect threshold of under 1 Gy.

TL;DR: The data suggest that ATM heterozygotes in the human population may also be radiosensitive and may influence the choice of individuals destined to be exposed to higher than normal doses of radiation, such as astronauts, and may also suggest that radiotherapy patients that are heterozygous for the ATM gene could be predisposed to increased late normal tissue damage.

TL;DR: Administration of L-BSO to preweanling mice provides a novel model system for the induction of cataracts by depletion of lens glutathione and may enable the study of critical functions of glutATHione in the lens and other growing tissues during early postnatal development.

TL;DR: The migration of epithelial cells during fibergenesis in the lenses of young rats was determined by tritiated thymidine autoradiography and the presence of labeled cells in those regions prior to the onset of opacification is consistent with the possibility of direct epithelial cell involvement in radiation cataractogenesis.

TL;DR: Evidence is reviewed indicating a primary role for the lens epithelium in the loss of transparency of the cortex and the concept of the "cataractotoxic load" and its applicability to the development of human senile cortical cataracts is discussed.