Bastian Mühl

TL;DR: It is concluded that inhibition of ribosome biogenesis by chemotherapeutic drugs potentially may contribute to the efficacy of therapeutic regimens.

TL;DR: It is shown that 4sU-tagging at low concentrations ≤ 10 µM can be used to measure production and processing of ribosomal (r)RNA, and it is concluded that metabolic labeling of RNA by 4s U triggers a nucleolar stress response, which might influence the interpretation of results.

TL;DR: It is concluded that DDX27 can interact specifically with the Pes1 and Bop1 but fulfils critical function(s) for proper 3' end formation of 47S rRNA independently of the PeBoW-complex.

TL;DR: The data demonstrate a pivotal role of Cdk9 activity for coupling of RNAPII transcription with small nucleolar RNA production and rRNA processing, and indicate that defective 3′ processing of rRNA negatively feeds back on RNAPI transcription.

TL;DR: Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions that responds to non-genotoxic cell stress, in particular if ribosome biogenesis is affected.