Caroline C. Friedel

TL;DR: An improved approach to separate total cellular RNA into newly transcribed and preexisting RNA following 10-15 min of metabolic labeling is developed and a previously undisclosed highly connected network of short-lived transcripts selectively down-regulated by IFNgamma is identified.

TL;DR: This study assigns specific functions to distinct fibronectin-binding integrins, demonstrating that α5β1integrins accomplish force generation, whereas αv-class Integrins mediate the structural adaptations to forces, which cooperatively enable cells to sense the rigidity of fibronECTin-based microenvironments.

TL;DR: Overexpression of NSP1 and infection with live SARS-CoV strongly increased signalling through the Calcineurin/NFAT pathway and enhanced the induction of interleukin 2, compatible with late-stage immunopathogenicity and long-term cytokine dysregulation as observed in severe SARS cases.

TL;DR: A comprehensive proteomic analysis of nascent and mature adhesions suggests a common recruitment mechanism for a whole class of adhesion‐associated proteins, involving myosin II and the zinc‐finger‐type LIM domain.

TL;DR: This work shows that different regulatory patterns between functionally similar proteins are characterized by differences in the half-life of the corresponding transcripts and can be identified by measuring RNA half- life, and predicts more than 100 protein families which show such differential regulatory patterns in both species.