Lukas Windhager

TL;DR: A comprehensive blind assessment of over 30 network inference methods on Escherichia coli, Staphylococcus aureus, Saccharomyces cerevisiae and in silico microarray data defines the performance, data requirements and inherent biases of different inference approaches, and provides guidelines for algorithm application and development.

TL;DR: The genome sequence of the duodenal ulcer strain P12 and six other H. pylori genomes are compared to elucidate the genetic repertoire and genome evolution mechanisms of this species and it is demonstrated for the first time that one of these islands is capable of self-excision and horizontal transfer by a conjugative process.

TL;DR: It is shown that ultrashort 4sU-tagging not only provides snapshot pictures of eukaryotic gene expression but also reveals global RNA processing kinetics at nucleotide resolution and provides the tools to study molecular mechanisms of RNA processing and their contribution to the regulation of gene expression.

TL;DR: A new score for network inference, η(2), that is derived from an analysis of variance that has a number of interesting features that enable the efficient detection of gene regulatory interactions.

TL;DR: It is shown that 4sU-tagging at low concentrations ≤ 10 µM can be used to measure production and processing of ribosomal (r)RNA, and it is concluded that metabolic labeling of RNA by 4s U triggers a nucleolar stress response, which might influence the interpretation of results.