Bastien Nay

TL;DR: A phytochemical update will be provided and the total synthesis of alkaloids and terpenoids will be discussed in detail, as Homoharringtonine is active against some orphan leukaemia and is nowadays approaching marketability.

TL;DR: In this article, the structural originality of these compounds, their biological properties and the synthetic efforts developed to reach them are discussed, and 157 references are cited; the review aims to emphasize the structural uniqueness and biological properties of the compounds.

TL;DR: Paraconiothyrium variabile, one of the specific endophytic fungi isolated from the host plant Cephalotaxus harringtonia, possesses the faculty to inhibit the growth of common phytopathogens, thus suggesting a role in its host protection.

TL;DR: Out of more than a thousand molecules present in the crude extract of the plant leaf, a specific biotransformation of glycosylated flavonoids by the endophyte led to the production of the corresponding aglycone via deglycosylation, illustrating the chemical cooperation underlying the mutualistic relationship between the plant and the startophyte.

TL;DR: Harringtonolide (= hainanolide) is a complex polycyclic fused norditerpene isolated from CEPHALOTAXUS HARRINGTONIA var.