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Beat Ernst
Researcher at University of Basel
Publications - 317
Citations - 8640
Beat Ernst is an academic researcher from University of Basel. The author has contributed to research in topics: Glycosylation & Ligand (biochemistry). The author has an hindex of 43, co-authored 315 publications receiving 7924 citations. Previous affiliations of Beat Ernst include Hoffmann-La Roche & Novartis.
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Journal ArticleDOI
Drug Discovery Today
TL;DR: A wide range of new lead finding and lead optimization opportunities result from novel screening methods by NMR, which are the topic of this review article.
Journal ArticleDOI
From carbohydrate leads to glycomimetic drugs
Beat Ernst,John L. Magnani +1 more
TL;DR: Examples of approved carbohydrate-derived drugs are examined, the potential of carbohydrate-binding proteins as new drug targets are discussed (focusing on the lectin families) and ways to overcome the challenges of developing this unique class of novel therapeutics are considered.
MonographDOI
Carbohydrates in chemistry and biology
TL;DR: This four-volume handbook presents an integrated and cutting-edge view of Glycoscience, and covers all chemical aspects, such as syntheses and analysis of carbohydrates and oligosaccharides, as well as the biological role and activity of oligosACcharides and carbohydrate/protein interactions.
Journal ArticleDOI
GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.
TL;DR: It is found that GMI-1070 predominantly inhibited E-selectin-mediated adhesion and dramatically inhibited sRBC-leukocyte interactions, leading to improved microcirculatory blood flow and improved survival.