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Beat Ernst
Researcher at University of Basel
Publications - 317
Citations - 8640
Beat Ernst is an academic researcher from University of Basel. The author has contributed to research in topics: Glycosylation & Ligand (biochemistry). The author has an hindex of 43, co-authored 315 publications receiving 7924 citations. Previous affiliations of Beat Ernst include Hoffmann-La Roche & Novartis.
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Journal ArticleDOI
Kinetic Properties of Carbohydrate–Lectin Interactions: FimH Antagonists
Meike Scharenberg,Xiaohua Jiang,Lijuan Pang,Giulio Navarra,Said Rabbani,Florian P. C. Binder,Oliver Schwardt,Beat Ernst +7 more
TL;DR: The long t1/2 value of the tested FimH antagonists further confirms their drug‐like properties and their high therapeutic potential.
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Activities of N,N′-Diarylurea MMV665852 Analogs against Schistosoma mansoni
Noemi Cowan,Noemi Cowan,Philipp Dätwyler,Beat Ernst,Chunkai Wang,Jonathan L. Vennerstrom,Thomas Spangenberg,Jennifer Keiser,Jennifer Keiser +8 more
TL;DR: Several analogs of the N,N′-diarylurea MMV665852 had high efficacy against S. mansoni in vitro and favorable physicochemical properties for permeation through the intestinal wall, and further investigations should focus on identifying compounds with improved solubility and pharmacokinetic properties.
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Simulating α/β Selectivity at the Human Thyroid Hormone Receptor: Consensus Scoring Using Multidimensional QSAR
TL;DR: A consensus‐scoring study on the human thyroid hormone receptor α and β using two receptor‐modeling concepts (software Quasar and Raptor) that are based on multidimensional QSAR and allow for the explicit simulation of induced fit is presented.
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Low Molecular Weight Antagonists of the Myelin-Associated Glycoprotein: Synthesis, Docking, and Biological Evaluation
Stefanie Mesch,Delia Moser,Daniel S. Strasser,Antje Kelm,Brian Cutting,Gianluca Rossato,Angelo Vedani,Hendrik Koliwer-Brandl,Matthias Wittwer,Said Rabbani,Oliver Schwardt,Soerge Kelm,Beat Ernst +12 more
TL;DR: In this paper, the myelin-associated glycoprotein (MAG) was identified and the lead structure 5, which showed a 250-fold improved in vitro affinity for MAG compared to the tetrasaccharide binding epitope of GQ1balpha.