J
Jonathan L. Vennerstrom
Researcher at University of Nebraska Medical Center
Publications - 137
Citations - 6852
Jonathan L. Vennerstrom is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Artemisinin & Plasmodium falciparum. The author has an hindex of 44, co-authored 131 publications receiving 6356 citations. Previous affiliations of Jonathan L. Vennerstrom include Medicines for Malaria Venture & University of Nebraska–Lincoln.
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Journal ArticleDOI
Identification of an antimalarial synthetic trioxolane drug development candidate.
Jonathan L. Vennerstrom,Sarah Arbe-Barnes,Reto Brun,Susan A. Charman,Francis C. K. Chiu,Jacques Chollet,Yuxiang Dong,Arnulf Dorn,Daniel Hunziker,Hugues Matile,Kylie Anne McIntosh,Maniyan Padmanilayam,Josefina Santo Tomas,Christian Scheurer,Bernard Scorneaux,Yuanqing Tang,Heinrich Urwyler,Sergio Wittlin,William N. Charman +18 more
TL;DR: Here it is described how a synthetic peroxide antimalarial drug development candidate was identified in a collaborative drug discovery project.
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Oxidative stress in malaria parasite-infected erythrocytes: Host-parasite interactions
Katja Becker,Leann Tilley,Jonathan L. Vennerstrom,David L. Roberts,Stephen J. Rogerson,Hagai Ginsburg +5 more
TL;DR: The presently available knowledge on sources and detoxification pathways of reactive oxygen species in malaria parasite-infected red cells, on clinical aspects of redox metabolism and redox-related mechanisms of drug action as well as future prospects for drug development is summarized.
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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
Susan A. Charman,Sarah Arbe-Barnes,Ian Bathurst,Reto Brun,Michael Campbell,William N. Charman,Francis C. K. Chiu,Jacques Chollet,J. Carl Craft,Darren J. Creek,Yuxiang Dong,Hugues Matile,Melanie Maurer,Julia Morizzi,Tien Nguyen,Petros Papastogiannidis,Christian Scheurer,David M. Shackleford,Kamaraj Sriraghavan,Lukas Stingelin,Yuanqing Tang,Heinrich Urwyler,Xiaofang Wang,Karen L. White,Sergio Wittlin,Lin Zhou,Jonathan L. Vennerstrom +26 more
TL;DR: The outstanding efficacy and prolonged blood concentrations of OZ439 are the result of a design strategy that stabilizes the intrinsically unstable pharmacophoric peroxide bond, thereby reducing clearance yet maintaining the necessary Fe(II)-reactivity to elicit parasite death.
Journal ArticleDOI
An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials
Arnulf Dorn,Sudha Rani Vippagunta,Hugues Matile,Catherine Jaquet,Jonathan L. Vennerstrom,Robert G. Ridley +5 more
TL;DR: A correlation for eight antimalarial quinolines between inhibition of haematin polymerisation in vitro and inhibition of P. falciparum growth in culture is demonstrated, confirming haematar polymerisation as the likely target of quinoline blood schizonticides.
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Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines.
TL;DR: The thiazine dyes were the most uniformly potent structural class tested, and among the dyes in this class, methylene blue was notable for both its high antimalarial potency and selectivity.