Beatrice H.L. Wong

TL;DR: In a surveillance study for CoV in noncaged animals from the wild areas of the Hong Kong Special Administration Region, a CoV closely related to SARS-CoV is identified from 23 (39%) of 59 anal swabs of wild Chinese horseshoe bats by using RT-PCR and the presence of a 29-bp insertion in ORF 8 of bat-SARS- coV genome suggests that it has a common ancestor with civet SARS -CoV.

TL;DR: The data support the existence of a novel group 2 coronavirus associated with pneumonia in humans, CoV-HKU1, from a 71-year-old man with pneumonia who had just returned from Shenzhen, China.

TL;DR: Phylogenetic analysis of RNA-dependent-RNA-polymerase (pol) and helicase genes revealed six novel coronaviruses from six different bat species, in addition to the two previously described coronavirus in bats.

TL;DR: The high Ka/Ks ratio of NS7a and NS7b in bat-CoV HKU9 implies that these two group 2d-specific genes are under high selective pressure and hence are rapidly evolving, and the four subgroups of group 2 coronavirus probably originated from a common ancestor.

TL;DR: CoV-HKU1 accounts for 2.4% of community-acquired pneumonia, with 2 genotypes in the study population, without performance of diagnostic tests, the illness was clinically indistinguishable from other community- Acquired pneumonia illnesses.