Benette Phillips

TL;DR: It is reported here that hemin activates the DNA-binding activity of HSF2, whereas heat shock induces predominantly theDNA- binding activity of a distinct factor, HSF1, which constitutes the first example ofHSF2 activation in vivo.

TL;DR: Interestingly, altering the temperature at which cells are grown prior to heat shock modulates the magnitude and temporal pattern of the response to a given heat shock temperature, suggesting that HSF does not sense temperature directly but, instead, may be responsive to the magnitude of the difference between growth and heat shock temperatures.

TL;DR: The tagged 75-kDa protein localizes to mitochondria, thus providing conclusive evidence that it corresponds to the human mitochondrial hsp70, referred to here as mthsp75.

TL;DR: Genomic footprinting of the human hsp70 promoter reveals that heat shock induces a rapid binding of a factor, presumably heat shock transcription factor, to a region encompassing five contiguous NGAAN sequences, three perfect and two imperfect matches to the consensus sequence.

TL;DR: The results indicate that induction of these genes is not a general response to the stress of viral infection but is instead a highly specific response, both with regard to the inducing virus and with regards to the target gene.