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Benjamin Boyerinas
Researcher at National Institutes of Health
Publications - 16
Citations - 2360
Benjamin Boyerinas is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 9, co-authored 15 publications receiving 2114 citations. Previous affiliations of Benjamin Boyerinas include University of Chicago.
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Journal ArticleDOI
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death
TL;DR: The role of miRNAs and their targets in contributing to human cancers and their function as regulators of apoptotic pathways and the immune system are summarized.
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The role of let-7 in cell differentiation and cancer
TL;DR: The role of let-7 in normal development and differentiation is discussed, the regulation oflet-7 expression, cancer-relevantLet-7 targets, and the relationship between let-8 and drug sensitivity are highlighted, and an overview of the relationships between deregulated let- 7 expression and tumorigenesis is provided.
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Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells.
Benjamin Boyerinas,Caroline Jochems,Massimo Fantini,Christopher R. Heery,James L. Gulley,Kwong Y. Tsang,Jeffrey Schlom +6 more
TL;DR: The ability of avelumab to lyse a range of human tumor cells in the presence of PBMC or NK effectors is demonstrated and IFNγ can enhance tumor cell PD-L1 expression and, in some cases, enhance ADCC tumor cell lysis.
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Identification of Let-7–Regulated Oncofetal Genes
Benjamin Boyerinas,Sun Mi Park,Noam Shomron,Mads M. Hedegaard,Jeppe Vinther,Jens S. Andersen,Christine Feig,Christine Feig,Jinbo Xu,Christopher B. Burge,Marcus E. Peter +10 more
TL;DR: The data suggest that a substantial part of the growth inhibitory activities of let-7 comes from suppressing the expression of IMP-1, which could be novel therapeutic targets and potential biomarkers for cancer treatment.
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Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy
Benjamin Boyerinas,Maya Zafrir,Ali Ekrem Yesilkanal,Trevor T. Price,Elizabeth Hyjek,Dorothy A. Sipkins +5 more
TL;DR: It is shown that osteopontin (OPN), an extracellular matrix molecule secreted by osteoblasts, can function to anchor leukemic blasts in anatomic locations supporting tumor dormancy, and that this interaction induces cell cycle exit in leukedmic blasts, protecting them from cytotoxic chemotherapy.