Benjamin C. Cheah

TL;DR: This paper summarized current concepts about the origin of the disease, what predisposes patients to develop the disorder, and discuss why all cases of ALS are not the same, focusing on the small steps of extending longevity, improving therapies, undertaking clinical trials, and compiling population registries to the overarching goals of establishing the measures that guard against onset and finding the triggers for this neurodegenerative disorder.

TL;DR: The present review summarises the known chemical and pharmacological properties of riluzole, and the hypothesis that Na+ conductances may be involved in the processes of neuronal and axonal degeneration in ALS will be explored.

TL;DR: The threshold tracking TMS techniques may prove useful as a diagnostic investigation for ALS, and the presence of cortical hyperexcitability distinguishes ALS from mimic disorders.

TL;DR: It is established that riluzole exerts effects on both central and peripheral nerve function, interpreted as partial normalization of cortical hyperexcitability and reduction of transient Na+ conductances, which suggest that the neuroprotective effects of rilzole in amyotrophic lateral sclerosis are complex, with evidence of independent effects across both compartments of the nervous system.

TL;DR: In conclusion, inspiratory muscle training may potentially strengthen the inspiratory muscles and slow the decline in respiratory function in patients with ALS/MND.