Benjamin J. Seifer

TL;DR: Antimüllerian hormone has weak association with implantation and clinical pregnancy rates in assisted reproductive technology but may still have some clinical utility in counseling women undergoing fertility treatment regarding pregnancy rates, particularly those with DOR.

TL;DR: Several miRNAs in serum that distinguished subjects with endometriosis from those without were identified and miR-125b-5p had the greatest potential as a single diagnostic biomarker.

TL;DR: Transfection of Lin28 into gastric cancer cells increased their resistance to the chemo-drugs oxaliplatin, paclitaxel (PTX), doxorubicin (ADM), and fluorouracil (5-Fu) compared with gastriccancer cells transfected with a control vector and it was found that miR-107 is a target microRNA ofLin28 and that it participates in the mechanism of chemotherapy resistance.

TL;DR: Serum let-7 family miRNA shows similar dysregulation in endometriosis in both humans and mice, and diminished circulatingLet-7 implies a complex regulation that potentially involves multiple organs.

TL;DR: The let- 7-dependent and let-7-independent mechanism regulated by Lin28 is summarized, focusing on its relation with tumor hallmarks in breast cancer, and the present knowledge of Lin28 to develop a molecular-based therapeutic strategy against breast cancer is discussed.