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Benjamin Z. Leder
Researcher at Harvard University
Publications - 99
Citations - 6128
Benjamin Z. Leder is an academic researcher from Harvard University. The author has contributed to research in topics: Osteoporosis & Denosumab. The author has an hindex of 35, co-authored 94 publications receiving 5319 citations. Previous affiliations of Benjamin Z. Leder include Endocrine Society.
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Journal ArticleDOI
Denosumab in men receiving androgen-deprivation therapy for prostate cancer
Matthew R. Smith,Blair Egerdie,Narciso Hernández Toriz,Robert G. Feldman,Teuvo L.J. Tammela,Fred Saad,Jiri Heracek,Maciej Szwedowski,Chunlei Ke,Amy Kupic,Benjamin Z. Leder,Carsten Goessl +11 more
TL;DR: Denosumab was associated with increased bone mineral density at all sites and a reduction in the incidence of new vertebral fractures among men receiving androgen-deprivation therapy for nonmetastatic prostate cancer.
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Gonadal steroids and body composition, strength, and sexual function in men.
Joel S. Finkelstein,Hang Lee,Sherri-Ann M. Burnett-Bowie,J. Carl Pallais,Elaine W. Yu,Lawrence F. Borges,Brent F. Jones,Christopher V. Barry,Kendra E. Wulczyn,Bijoy J. Thomas,Benjamin Z. Leder +10 more
TL;DR: Changes in the percentage of body fat and in lean mass were the primary outcomes and subcutaneous- and intraabdominal-fat areas, thigh-muscle area and strength, and sexual function were assessed.
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Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial
Joy N. Tsai,Alexander V. Uihlein,Hang Lee,Ruchit Kumbhani,Erica Siwila-Sackman,Elizabeth A. McKay,Sherri-Ann M. Burnett-Bowie,Robert M. Neer,Benjamin Z. Leder +8 more
TL;DR: Combination teriparatide and denosumab increased BMD more than either agent alone and more than has been reported with approved therapies and might be useful to treat patients at high risk of fracture.
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Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial
Benjamin Z. Leder,Joy N. Tsai,Alexander V. Uihlein,Paul M. Wallace,Hang Lee,Robert M. Neer,Sherri-Ann M. Burnett-Bowie +6 more
TL;DR: The DATA-Switch study aimed to assess the changes in bone mineral density in postmenopausal osteoporotic women who transitioned between treatments, and showed that combined teriparatide and denosumab increased bone mineraldensity more than either drug alone.
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Differential Effects of Androgens and Estrogens on Bone Turnover in Normal Men
TL;DR: The data suggest that both androgens and estrogens play independent and fundamental roles in regulating bone resorption in men and suggest that androgens may play an important role in the regulation of bone formation in men.