F
Fred Saad
Researcher at Université de Montréal
Publications - 1141
Citations - 61312
Fred Saad is an academic researcher from Université de Montréal. The author has contributed to research in topics: Prostate cancer & Medicine. The author has an hindex of 92, co-authored 942 publications receiving 49530 citations. Previous affiliations of Fred Saad include University of Turin & National Institutes of Health.
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Journal ArticleDOI
Abiraterone and Increased Survival in Metastatic Prostate Cancer
Johann S. de Bono,Christopher J. Logothetis,Arturo Molina,Karim Fizazi,Scott North,Luis Chu,Kim N. Chi,Robert Jones,Oscar B. Goodman,Fred Saad,John Staffurth,Paul N. Mainwaring,S. J. Harland,Thomas W. Flaig,Thomas E. Hutson,Tina Cheng,Helen Patterson,John D. Hainsworth,Charles J. Ryan,Cora N. Sternberg,Susan Ellard,Aude Flechon,Mansoor N. Saleh,Mark C. Scholz,Eleni Efstathiou,Andrea Zivi,Diletta Bianchini,Yohann Loriot,Nicole Chieffo,Thian Kheoh,Christopher M. Haqq,Howard I. Scher +31 more
TL;DR: The inhibition of androgen biosynthesis by abiraterone acetate prolonged overall survival among patients with metastatic castration-resistant prostate cancer who previously received chemotherapy.
Journal ArticleDOI
Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy
Howard I. Scher,Karim Fizazi,Fred Saad,Mary-Ellen Taplin,Cora N. Sternberg,Kurt Miller,Ronald de Wit,Peter F.A. Mulders,Kim N. Chi,Neal D. Shore,Andrew J. Armstrong,Thomas W. Flaig,Aude Flechon,Paul N. Mainwaring,Mark D. Fleming,John D. Hainsworth,Mohammad Hirmand,Bryan Selby,Lynn Seely,Johann S. de Bono,B Ch +20 more
TL;DR: Enzalutamide significantly prolonged the survival of men with metastatic castration-resistant prostate cancer after chemotherapy, and was shown with respect to all secondary end points.
Journal ArticleDOI
Enzalutamide in Metastatic Prostate Cancer before Chemotherapy
Tomasz M. Beer,Andrew J. Armstrong,Dana E. Rathkopf,Yohann Loriot,Cora N. Sternberg,Celestia S. Higano,Peter Iversen,Suman Bhattacharya,Joan Carles,Simon Chowdhury,Ian D. Davis,Johann S. de Bono,Christopher P. Evans,Karim Fizazi,Anthony M. Joshua,Choung-Soo Kim,Go Kimura,Paul N. Mainwaring,Harry H. Mansbach,Kurt Miller,Sarah B. Noonberg,Frank Perabo,De Phung,Fred Saad,Howard I. Scher,Mary-Ellen Taplin,Peter Venner,Bertrand Tombal +27 more
TL;DR: Enzalutamide significantly decreased the risk of radiographic progression and death and delayed the initiation of chemotherapy in men with metastatic prostate cancer.
Journal ArticleDOI
Abiraterone in Metastatic Prostate Cancer without Previous Chemotherapy
Charles J. Ryan,Matthew R. Smith,Johann S. de Bono,Arturo Molina,Christopher J. Logothetis,Paul de Souza,Karim Fizazi,Paul N. Mainwaring,Josep M. Piulats,Siobhan Ng,Joan Carles,Peter F.A. Mulders,Ethan Basch,Eric J. Small,Fred Saad,D. Schrijvers,Hendrik Van Poppel,Som D. Mukherjee,Henrik Suttmann,Winald R. Gerritsen,Thomas W. Flaig,Daniel J. George,Evan Y. Yu,Eleni Efstathiou,Allan J. Pantuck,Eric Winquist,Celestia S. Higano,Mary-Ellen Taplin,Youn C. Park,Thian Kheoh,Thomas W. Griffin,Howard I. Scher,Dana E. Rathkopf +32 more
TL;DR: Abiraterone improved radiographic progression-free survival, showed a trend toward improved overall survival, and significantly delayed clinical decline and initiation of chemotherapy in patients with metastatic castration-resistant prostate cancer.
Journal ArticleDOI
The Molecular Taxonomy of Primary Prostate Cancer
Adam Abeshouse,Jaeil Ahn,Rehan Akbani,Adrian Ally,Samirkumar B. Amin,Christopher D. Andry,Matti Annala,Armen Aprikian,Joshua Armenia,Arshi Arora,J. Todd Auman,Miruna Balasundaram,Saianand Balu,Christopher E. Barbieri,Thomas L. Bauer,Christopher C. Benz,Alain Bergeron,Rameen Beroukhim,Mario Berrios,Adrian Bivol,Tom Bodenheimer,Lori Boice,Moiz S. Bootwalla,Rodolfo Borges Dos Reis,Paul C. Boutros,Jay Bowen,Reanne Bowlby,Jeff Boyd,Robert K. Bradley,Anne Breggia,Fadi Brimo,Christopher A. Bristow,Denise Brooks,Bradley M. Broom,Alan H. Bryce,Glenn Bubley,Eric J. Burks,Yaron S.N. Butterfield,Michael Button,David Canes,Carlos Gilberto Carlotti,Rebecca Carlsen,Michel Carmel,Peter R. Carroll,Scott L. Carter,Richard Cartun,Brett S. Carver,June M. Chan,Matthew T. Chang,Yu Chen,Andrew D. Cherniack,Simone Chevalier,Lynda Chin,Juok Cho,Andy Chu,Eric Chuah,Sudha Chudamani,Kristian Cibulskis,Giovanni Ciriello,Amanda Clarke,Matthew R. Cooperberg,Niall M. Corcoran,Anthony J. Costello,Janet E. Cowan,Daniel Crain,Erin Curley,Kerstin David,John A. Demchok,Francesca Demichelis,Noreen Dhalla,Rajiv Dhir,Alexandre Doueik,Bettina F. Drake,Heidi Dvinge,Natalya Dyakova,Ina Felau,Martin L. Ferguson,Scott Frazer,Stephen J. Freedland,Yao Fu,Stacey Gabriel,Jianjiong Gao,Johanna Gardner,Julie M. Gastier-Foster,Nils Gehlenborg,Mark Gerken,Mark Gerstein,Gad Getz,Andrew K. Godwin,Anuradha Gopalan,Markus Graefen,Kiley Graim,Thomas Gribbin,Ranabir Guin,Manaswi Gupta,Angela Hadjipanayis,Syed Haider,Lucie Hamel,D. Neil Hayes,David I. Heiman,Julian M. Hess,Katherine A. Hoadley,Andrea Holbrook,Robert A. Holt,Antonia H. Holway,Christopher M. Hovens,Alan P. Hoyle,Mei Huang,Carolyn M. Hutter,Michael Ittmann,Lisa Iype,Stuart R. Jefferys,Corbin D. Jones,Steven J.M. Jones,Hartmut Juhl,Andre Kahles,Christopher J. Kane,Katayoon Kasaian,Michael Kerger,Ekta Khurana,Jaegil Kim,Robert J. Klein,Raju Kucherlapati,Louis Lacombe,Marc Ladanyi,Phillip H. Lai,Peter W. Laird,Eric S. Lander,Mathieu Latour,Michael S. Lawrence,Kevin Lau,Tucker W. LeBien,Darlene Lee,Semin Lee,Kjong-Van Lehmann,Kristen M. Leraas,Ignaty Leshchiner,Robert Leung,John A. Libertino,Tara M. Lichtenberg,Pei Lin,W. Marston Linehan,Shiyun Ling,Scott M. Lippman,Jia Liu,Wen-Bin Liu,Lucas Lochovsky,Massimo Loda,Christopher J. Logothetis,Laxmi Lolla,Teri A. Longacre,Yiling Lu,Jianhua Luo,Yussanne Ma,Harshad S. Mahadeshwar,David Mallery,Armaz Mariamidze,Marco A. Marra,Michael Mayo,Shannon J. McCall,Ginette McKercher,Shaowu Meng,Anne Marie Mes-Masson,Maria J. Merino,Matthew Meyerson,Piotr A. Mieczkowski,Gordon B. Mills,Kenna R. Mills Shaw,Sarah Minner,Alireza Moinzadeh,Richard A. Moore,Scott Morris,Carl Morrison,Lisle E. Mose,Andrew J. Mungall,Bradley A. Murray,Jerome Myers,Rashi Naresh,Joel Nelson,Mark Nelson,Peter S. Nelson,Yulia Newton,Michael S. Noble,Houtan Noushmehr,Matti Nykter,Angeliki Pantazi,Michael Parfenov,Peter J. Park,Joel S. Parker,Joseph Paulauskis,Robert Penny,Charles M. Perou,Alain Piché,Todd Pihl,Peter A. Pinto,Davide Prandi,Alexei Protopopov,Nilsa C. Ramirez,Arvind Rao,W. Kimryn Rathmell,Gunnar Rätsch,Xiaojia Ren,Victor E. Reuter,Sheila Reynolds,Suhn K. Rhie,Kimberly Rieger-Christ,Jeffrey Roach,A. Gordon Robertson,Brian D. Robinson,Mark A. Rubin,Fred Saad,Sara Sadeghi,Gordon Saksena,Charles Saller,Andrew Salner,Francisco Sanchez-Vega,Chris Sander,George E. Sandusky,Guido Sauter,Andrea Sboner,Peter T. Scardino,Eleonora Scarlata,Jacqueline E. Schein,Thorsten Schlomm,Laura S. Schmidt,Nikolaus Schultz,Steven E. Schumacher,Jonathan G. Seidman,Luciano Neder,Sahil Seth,Alexis Sharp,Candace Shelton,Troy Shelton,Hui Shen,Ronglai Shen,Mark E. Sherman,Margi Sheth,Yan Shi,Juliann Shih,Ilya Shmulevich,Jeffry Simko,Ronald Simon,Janae V. Simons,Payal Sipahimalani,Tara Skelly,Heidi J. Sofia,Matthew G. Soloway,Xingzhi Song,Andrea Sorcini,Carrie Sougnez,Serghei Stepa,Chip Stewart,John A. Stewart,Joshua M. Stuart,Travis Sullivan,Charlie Sun,Huandong Sun,Angela Tam,Donghui Tan,Jiabin Tang,Roy Tarnuzzer,Katherine Tarvin,Barry S. Taylor,Patrick Teebagy,Imelda Tenggara,Bernard Têtu,Ashutosh Tewari,Nina Thiessen,Timothy C. Thompson,Leigh B. Thorne,Daniela P. Tirapelli,Scott A. Tomlins,Felipe Amstalden Trevisan,Patricia Troncoso,Lawrence D. True,Maria Christina Tsourlakis,Svitlana Tyekucheva,Eliezer M. Van Allen,David Van Den Berg,Umadevi Veluvolu,Roeland Verhaak,Cathy D. Vocke,Doug Voet,Yunhu Wan,Qingguo Wang,Wenyi Wang,Zhining Wang,Nils Weinhold,John N. Weinstein,Daniel J. Weisenberger,Matthew D. Wilkerson,Lisa Wise,John S. Witte,Chia Chin Wu,Junyuan Wu,Ye Wu,Andrew Wei Xu,Shalini S. Yadav,Liming Yang,Lixing Yang,Christina Yau,Huihui Ye,Peggy Yena,Thomas Zeng,Jean C. Zenklusen,Hailei Zhang,Jianhua Zhang,Jiashan Zhang,Wei Zhang,Yi Zhong,Kelsey Zhu,Erik Zmuda +311 more
TL;DR: The Cancer Genome Atlas (TCGA) has been used for a comprehensive molecular analysis of primary prostate carcinomas as discussed by the authors, revealing substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course.