Benno Kuropka

TL;DR: A DNA-encoded library screen is reported leading to the discovery of BAY-850, a potent and isoform selective inhibitor that specifically induces ATAD2 bromodomain dimerization and prevents interactions with acetylated histones in vitro, as well as with chromatin in cells.

TL;DR: The data support the hypothesis of an endogenously poised cytokine profile in neonates and suggest a link between cytokine production and the developmental stage of an organism.

TL;DR: This design and benchmarking of a new algorithm allowing the identification and label-free quantification (LFQ) of shared consensus epitopes arising from series of nested peptides and reveals that while for certain autoimmune-relevant epitopes their presentation increases upon DM expression others are clearly edited out from the peptidome.

TL;DR: Primary T cells are used with acyl-biotin exchange and quantitative mass spectrometry to identify a pool of proteins previously unreported as palmitoylated in vivo, affecting the function of receptors and intracellular signaling proteins.

TL;DR: It is found that the presence of soldiers of the Darwin termite, Mastotermes darwiniensis, significantly improves the survival of nestmates following entomopathogenic infection, and the oral secretions produced by soldiers are sufficient to protect nestmates against infection.