Benno Verbelen

TL;DR: The R98S mutation in ribosomal protein L10 affects 8% of pediatric T-cell acute lymphoblastic leukemia cases, and was previously described to impair cellular proliferation, and is revealed to accumulate reactive oxygen species which promotes mitochondrial dysfunction and reduced ATP levels, causing the proliferation defect.

TL;DR: It is shown that the ribosomal protein RPL10 promotes proliferation of T-ALL cells by upregulating the serine biosynthesis enzyme phosphoserine phosphatase which in turn modulates serine and glycine metabolism.

TL;DR: Molecular insights are provided into the repurposed mode-of-action of the antidepressant sertraline and a hitherto unidentified group of cancers is delineated being particularly sensitive to treatment with sERTraline, highlighting the simultaneous inhibition of serine/glycine synthesis and mitochondrial metabolism as a novel treatment strategy for serine/.

TL;DR: This study provides molecular insights into the repurposed mode-of-action of the antidepressant sertraline and allows to delineate a hitherto unidentified group of cancers being particularly sensitive to treatment with sertrals, and highlights the simultaneous inhibition of serine/glycine synthesis and mitochondrial metabolism as a novel treatment strategy for serine-glycines addicted cancers.

TL;DR: Following the publication of this article, the authors noted that Dr Laura Fancello was not listed among the authors and the corrected author list is given below.