B
Benoit Marabout
Researcher at Sanofi S.A.
Publications - 62
Citations - 606
Benoit Marabout is an academic researcher from Sanofi S.A.. The author has contributed to research in topics: Alkyl & Carboxamide. The author has an hindex of 11, co-authored 62 publications receiving 591 citations.
Papers
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Journal ArticleDOI
Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic.
Ronan Depoortère,Gihad Dargazanli,Genevieve Estenne-Bouhtou,Annick Coste,Christophe Lanneau,C. Desvignes,Martine Poncelet,Michel Heaulme,Vincent Santucci,Michel Decobert,Annie Cudennec,Carolle Voltz,Denis Boulay,Jean Paul Terranova,Jeanne Stemmelin,Pierre Roger,Benoit Marabout,Mireille Sevrin,Xavier Vigé,Bruno Biton,Régis Steinberg,Dominique Françon,R. Alonso,Patrick Avenet,F. Oury-Donat,Ghislaine Perrault,Guy Griebel,Pascal George,Philippe Soubrie,Bernard Scatton +29 more
TL;DR: SSR504734 is a potent and selective GlyT1 inhibitor, exhibiting activity in schizophrenia, anxiety and depression models, and is expected to be efficacious not only against positive but also negative symptoms, cognitive deficits, and comorbid depression/anxiety states.
Journal ArticleDOI
SSR180575 (7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a Peripheral Benzodiazepine Receptor Ligand, Promotes Neuronal Survival and Repair
Badia Ferzaz,Emmanuel Brault,Genevieve Bourliaud,Jean-Pierre Robert,Gilles Poughon,Y. Claustre,Franck Marguet,Philippe Liere,Michael Schumacher,Jean-Pierre Nowicki,Jacqueline Fournier,Benoit Marabout,Mireille Sevrin,Pascal George,Philippe Soubrie,Jesus Benavides,Bernard Scatton +16 more
TL;DR: The results indicate that PBR ligands (e.g., SSR180575) promote neuronal survival and repair in axotomy and neuropathy models and have potential for the treatment of neurodegenerative diseases.
Patent
Derivatives of n-phenyl(piperidin-2-yl)methyl benzamide, the preparation method thereof and application of same in therapeutics
Dargazanli Gihad,Bouhtou Genevieve Estenne,Magat Pascale,Benoit Marabout,Florence Medaisko,Roger Pierre,Mireille Sevrin,Corinne Veronique +7 more
TL;DR: In this article, a general formula for compounds having general formula (I) was proposed, where A denotes a hydrogen atom or one or more substituents selected from the halogen atoms and the trifluoromethyl, alkyl, alkoxy, amino groups.
Patent
N-[phenyl (piperidin-2-yl) methyl]benzamide derivatives, preparation thereof, and use thereof in therapy
TL;DR: In this paper, compounds of general formula (I) were defined, where R represents a hydrogen atom, X represents one or several substituents selected among halogen atoms and trifluoromethyl, alkyl, and alkoxy groups.
Patent
Use of tricyclic compounds as glycine transport inhibitors
TL;DR: In this article, the authors defined a general formula (I) for a compound having general activity as specific inhibitors of glyt1 and/or glyt2 transporters, where R represents a hydrogen atom or a vinyl group; n represents 0, 1 or 2; X represents a groups having formula CH or a nitrogen atom; R1 represents a phenyl or naphthyl group, or a cyclohexyl group or a heteroaryl group; R2 represents a gas atom, or one or more substituents selected from among the halogen atoms and the