B
Bernadette Mouzon
Researcher at GlaxoSmithKline
Publications - 3
Citations - 122
Bernadette Mouzon is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Cancer & Mutant. The author has an hindex of 3, co-authored 3 publications receiving 100 citations.
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Journal ArticleDOI
Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors
Emmanuel Hubert Demont,Chun-wa Chung,Rebecca C. Furze,Paola Grandi,Anne-Marie Michon,Christopher Roland Wellaway,Nathalie Barrett,Angela Bridges,Peter D. Craggs,Hawa Diallo,David P. Dixon,Clement Douault,Amanda Emmons,Emma J. Jones,Bhumika Karamshi,Kelly Locke,Darren Jason Mitchell,Bernadette Mouzon,Rab K. Prinjha,Andrew D. Roberts,Robert J. Sheppard,Robert J. Watson,Paul Bamborough +22 more
TL;DR: The discovery of a hit from a fragment-based targeted array is described, which produced the first known micromolar inhibitors of the ATAD2 bromodomain.
Journal ArticleDOI
Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses.
Rachel Grimley,Oxana Polyakova,Jessica Vamathevan,Joanne McKenary,Brian Hayes,Champa Patel,Janet L. Smith,Angela Bridges,Andrew P. Fosberry,Anshu Bhardwaja,Bernadette Mouzon,Chun-wa Chung,Nathalie Barrett,Nicola J. Richmond,Sundip Modha,Roberto Solari +15 more
TL;DR: It is confirmed in cellular assays that SIRT6 can deacetylate acetylated-histone H3 lysine 9 (H3K9Ac), however this de acetylase activity is unusually low in biochemical assays.
Journal ArticleDOI
Rapid Lentiviral Vector Producer Cell Line Generation Using a Single DNA Construct.
Yu Hua Chen,Celeste Pallant,Christopher J. Sampson,Alessia Boiti,Sabine Johnson,Pijus Brazauskas,P. Hardwicke,Michela Marongiu,Vanesa M. Marinova,Marlene Carmo,Nathan P. Sweeney,Ashkenaz Richard,Anthony Shillings,Peter Archibald,Eva Puschmann,Bernadette Mouzon,David Grose,Miriam Mendez-Tavio,Mao Xiang Chen,Stephen R.C. Warr,Tarik Senussi,Paul S. Carter,Sean Baker,Cindy Jung,Martijn H. Brugman,Steven J. Howe,Conrad A. Vink +26 more
TL;DR: By removing the requirement for efficient transient transfection during upstream processing of lentiviral vectors and switching to an inherently scalable suspension cell culture format, it is believed that this approach will result in significantly higher batch yields than are possible with current manufacturing processes and enable better patient access to medicines based on lentivirus vectors.