M
Martijn H. Brugman
Researcher at Leiden University Medical Center
Publications - 62
Citations - 5415
Martijn H. Brugman is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 31, co-authored 62 publications receiving 4942 citations. Previous affiliations of Martijn H. Brugman include Erasmus University Medical Center & Max Delbrück Center for Molecular Medicine.
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Journal ArticleDOI
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
Steven J. Howe,Marc R. Mansour,Kerstin Schwarzwaelder,Cynthia C. Bartholomae,Mike Hubank,Helena Kempski,Martijn H. Brugman,Karin Pike-Overzet,S Chatters,Dick de Ridder,Dick de Ridder,Kimberly Gilmour,Stuart Adams,Susannah I. Thornhill,Kathryn L. Parsley,Frank J. T. Staal,Rosemary E. Gale,David C. Linch,Jinhua Bayford,Lucie Brown,Michelle Quaye,Christine Kinnon,Philip Ancliff,David Webb,Manfred Schmidt,Christof von Kalle,H. Bobby Gaspar,Adrian J. Thrasher +27 more
TL;DR: The occurrence of clonal T cell acute lymphoblastic leukemia (T-ALL) promoted by insertional mutagenesis in a completed gene therapy trial of 10 SCID-X1 patients is described and a general toxicity of endogenous gammaretroviral enhancer elements is highlighted.
Journal ArticleDOI
Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors
Ute Modlich,Susana Navarro,Daniela Zychlinski,Tobias Maetzig,S Knoess,Martijn H. Brugman,Axel Schambach,Sabine Charrier,Anne Galy,Adrian J. Thrasher,Juan A. Bueren,Christopher Baum,Christopher Baum +12 more
TL;DR: Mechanistic studies support the conclusion that enhancer-mediated gene activation is the major cause for insertional transformation of hematopoietic cells, opening rational strategies for risk prevention.
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Multipotent Stromal Cells Induce Human Regulatory T Cells Through a Novel Pathway Involving Skewing of Monocytes Toward Anti-inflammatory Macrophages
Sara M. Melief,Ellen Schrama,Martijn H. Brugman,Machteld M. Tiemessen,Martin J. Hoogduijn,Willem E. Fibbe,Helene Roelofs +6 more
TL;DR: Using an in vitro culture system, it was shown that culture‐expanded bone marrow‐derived MSC promote the generation of CD4+CD25hiFoxP3+ T cells in human PBMC populations and that these populations are functionally suppressive.
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Stimulation of Id1 Expression by Bone Morphogenetic Protein Is Sufficient and Necessary for Bone Morphogenetic Protein–Induced Activation of Endothelial Cells
Gudrun Valdimarsdottir,Marie-José Goumans,Alexander Rosendahl,Martijn H. Brugman,Susumu Itoh,Franck Lebrin,Paschalis Sideras,Peter ten Dijke +7 more
TL;DR: The BMP/Smad pathway can potently activate the endothelium and Id1 expression is strongly induced by BMP in ECs, and played a critical role in mediating BMP-induced EC migration.
Journal ArticleDOI
Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion
Tiago C. Luis,Tiago C. Luis,Brigitta A.E. Naber,Brigitta A.E. Naber,Paul P.C. Roozen,Martijn H. Brugman,Edwin F. E. de Haas,Mehrnaz Ghazvini,Willem E. Fibbe,Jacques J.M. van Dongen,Riccardo Fodde,Frank J. T. Staal,Frank J. T. Staal +12 more
TL;DR: In this paper, the effect of different mutations in the Adenomatous polyposis coli gene (Apc), a negative modulator of the canonical Wnt pathway, was analyzed.