Showing papers by "Bernard Mazoyer published in 2005"
TL;DR: These results indicate that an active blood pressure–lowering regimen stopped or delayed the progression of white matter hyperintensities in patients with cerebrovascular disease.
Abstract: BACKGROUND: The prevalence of white matter hyperintensities (WMHs) detected on cerebral MRI is associated with hypertension, but it is not known whether blood pressure lowering can arrest their progression. We report here the results of an MRI substudy of PROGRESS (Perindopril Protection Against Recurrent Stroke Study), a randomized trial of blood pressure lowering in subjects with cerebrovascular disease. METHODS AND RESULTS: The substudy comprised 192 participants who had a cerebral MRI both at baseline and after a mean follow-up time of 36 months (SD=6.0 months). At the first MRI, WMHs were graded with a visual rating scale from A (no WMH) to D (severe WMH). Participants were assigned to a combination of perindopril plus indapamide (or their placebos; 58%) or to single therapy with perindopril (or placebo). At the time of the second MRI, the blood pressure reduction in the active arm compared with the placebo arm was 11.2 mm Hg for systolic blood pressure and 4.3 mm Hg for diastolic blood pressure. Twenty-four subjects (12.5%) developed new WMHs at follow-up. The risk of new WMH was reduced by 43% (95% CI -7% to 89%) in the active treatment group compared with the placebo group (P=0.17). The mean total volume of new WMHs was significantly reduced in the active treatment group (0.4 mm3 [SE=0.8]) compared with the placebo group (2.0 mm3 [SE=0.7]; P=0.012). This difference was greatest for patients with severe WMH at entry, 0.0 mm3 (SE=0) in the active treatment group versus 7.6 mm3 (SE=1.0) in the placebo group (P<0.0001). CONCLUSIONS: These results indicate that an active blood pressure-lowering regimen stopped or delayed the progression of WMHs in patients with cerebrovascular disease.
437 citations
TL;DR: Findings indicate that brain atrophy during the seventh and eighth decades of life is ubiquitous and proceeds at a rate that is not modulated by "Sex".
281 citations
TL;DR: Results indicate that the left VWFA would be the place where visual and verbal representations bind under the control of left semantic areas, and semantic areas were more active during word than non-word reading and co-activated by both reading and listening.
165 citations
TL;DR: The existence of an anomaly in left hemisphere specialization for language in schizophrenic subjects is demonstrated using functional magnetic resonance imaging.
100 citations
TL;DR: Findings indicate that, in the age range of this cohort, ApoE-4 effects on cortical atrophy and cognitive performances of healthy elderly are limited to epsilon(4) homozygous subjects.
98 citations
TL;DR: The relationship between the anatomical variability of the central sulcus and hand skill in two groups of young male subjects differing by handedness was explored, and it was shown that the maximum tapping rate of the non-dominant right hand was strongly correlated with the GMV of the ipsilateral CS but not significantly with that of the contralateral CS.
66 citations
Journal Article•
17 citations