B
Bernard R. Wilfred
Researcher at University of Kentucky
Publications - 17
Citations - 1584
Bernard R. Wilfred is an academic researcher from University of Kentucky. The author has contributed to research in topics: microRNA & Gene silencing. The author has an hindex of 16, co-authored 17 publications receiving 1454 citations. Previous affiliations of Bernard R. Wilfred include Washington University in St. Louis.
Papers
More filters
Journal ArticleDOI
Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways.
TL;DR: A review of the fascinating and fast-growing literature on miRNA regulation of metabolism leads researchers to believe that the future will provide researchers with many additional energizing revelations.
Journal ArticleDOI
CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing
Manasi Malik,James F. Simpson,Ishita Parikh,Bernard R. Wilfred,David W. Fardo,Peter T. Nelson,Steven Estus +6 more
TL;DR: This work elucidates the mechanism of action of the AD-associated polymorphism rs3865444 in the promoter of CD33, a member of the sialic acid-binding Ig-superfamily of lectins (SIGLECs) and suggests a novel model wherein SNP-modulated RNA splicing modulates CD33 function and, thereby, AD risk.
Journal ArticleDOI
miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease
Wang-Xia Wang,Bernard R. Wilfred,Sindhu K. Madathil,Guiliang Tang,Yanling Hu,James Dimayuga,Arnold J. Stromberg,Qingwei Huang,Kathryn E. Saatman,Peter T. Nelson +9 more
TL;DR: In vitro and in vivo studies indicate that regulation of GRN by miR-107 may be functionally important, and contributes to GRN expression regulation with implications for brain disorders.
Journal ArticleDOI
Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
Peter T. Nelson,Charles D. Smith,Erin L. Abner,Bernard R. Wilfred,Wang-Xia Wang,Janna H. Neltner,Michael D. Baker,David W. Fardo,Richard J. Kryscio,Stephen W. Scheff,Gregory A. Jicha,Kurt A. Jellinger,Linda J. Van Eldik,Frederick A. Schmitt +13 more
TL;DR: The published literature on HS-Aging provides strong evidence of an important and under-appreciated brain disease of aging and factors that are hypothesized to cause or modify the disease are discussed.
Journal ArticleDOI
Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes
TL;DR: RIP-Chip assays constitute an optimized, validated, direct, and high-throughput biochemical assay that provides data about specific miRNA:mRNA interactions, as well as global patterns of regulation by miRNAs.