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Wang-Xia Wang
Researcher at University of Kentucky
Publications - 48
Citations - 4604
Wang-Xia Wang is an academic researcher from University of Kentucky. The author has contributed to research in topics: microRNA & Hippocampal sclerosis. The author has an hindex of 26, co-authored 46 publications receiving 3979 citations. Previous affiliations of Wang-Xia Wang include Washington University in St. Louis & Boston University.
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Journal ArticleDOI
The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1
Wang-Xia Wang,Bernard W. Rajeev,Arnold J. Stromberg,Na Ren,Guiliang Tang,Qingwei Huang,Isidore Rigoutsos,Peter T. Nelson +7 more
TL;DR: Together, the coordinated application of miRNA profiling, Affymetrix microarrays, new bioinformatics predictions, in situ hybridization, and biochemical validation indicate that miR-107 may be involved in accelerated disease progression through regulation of BACE1.
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The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases.
John R. Finnerty,John R. Finnerty,Wang-Xia Wang,Wang-Xia Wang,Sébastien S. Hébert,Sébastien S. Hébert,Bernard R. Wilfred,Bernard R. Wilfred,Guogen Mao,Guogen Mao,Peter T. Nelson,Peter T. Nelson +11 more
TL;DR: The miR-15/107 group of microRNA genes is a fascinating topic of study for evolutionary biologists, miRNA biochemists, and clinically oriented translational researchers alike and the roles played by these miRNAs in human diseases are investigated.
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Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways.
TL;DR: A review of the fascinating and fast-growing literature on miRNA regulation of metabolism leads researchers to believe that the future will provide researchers with many additional energizing revelations.
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Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter.
TL;DR: The hypothesis that patterns of miRNA expression in cortical GM may contribute to AD pathogenetically is supported, because the aggregate change in mi RNA expression observed early in the disease would be predicted to cause profound changes in gene expression.
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MicroRNAs (miRNAs) in Neurodegenerative Diseases
TL;DR: An overview of the normal functions for miRNAs, including some of the newer concepts related to the human brain, are provided and a discussion is included with theoretical syntheses and possible future directions in exploring the nexus between miRNA and ND research.