B
Bernat Crosas
Researcher at Spanish National Research Council
Publications - 33
Citations - 2672
Bernat Crosas is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Ubiquitin & Proteasome. The author has an hindex of 18, co-authored 33 publications receiving 2525 citations. Previous affiliations of Bernat Crosas include Queen's University & Harvard University.
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Journal ArticleDOI
Multiple Associated Proteins Regulate Proteasome Structure and Function
David Leggett,John Hanna,Anna Borodovsky,Bernat Crosas,Marion Schmidt,Rohan T. Baker,Thomas Walz,Hidde L. Ploegh,Daniel Finley +8 more
TL;DR: Proteasome binding activates Ubp6 300-fold and is mediated by the ubiquitin-like domain of Ubp 6, which is required for function in vivo, and deubiquitination events catalyzed byUbp6 prevent translocation of ubiquit in the proteolytic core particle.
Journal ArticleDOI
Deubiquitinating Enzyme Ubp6 Functions Noncatalytically to Delay Proteasomal Degradation
John Hanna,Nathaniel A. Hathaway,Yoshiko Tone,Bernat Crosas,Bernat Crosas,Suzanne Elsasser,Donald S. Kirkpatrick,David Leggett,Steven P. Gygi,Randall W. King,Daniel Finley +10 more
TL;DR: It is shown here that Ubp6 has the capacity to delay the degradation of ubiquitinated proteins by the proteasome, indicating that Ub p6 has both deubiquitinating activity and prote asome-inhibitory activity.
Journal ArticleDOI
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.
Bernat Crosas,John Hanna,Donald S. Kirkpatrick,Dan Phoebe Zhang,Yoshiko Tone,Nathaniel A. Hathaway,Christa Buecker,David Leggett,Marion Schmidt,Randall W. King,Steven P. Gygi,Daniel Finley +11 more
TL;DR: A proteasome-dependent conjugating activity of Hul5 is reported that endows proteasomes with the capacity to extend ubiquitin chains and proposes that through dynamic remodeling of ubiquit in chains, prote asomes actively regulate substrate commitment to degradation.
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Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1.
Emma Borràs,Christiane Coutelle,Albert Rosell,Fina Fernández-Muixi,Montserrat Broch,Bernat Crosas,Lars Hjelmqvist,Alfons Lorenzo,Cristina Gutierrez,Mauro Santos,Małgorzata Szczepanek,Markus Heilig,Pierrette Quattrocchi,Jaume Farrés,Francesc Vidal,Cristóbal Richart,Tomasz Mach,Bogdał J,Hans Jörnvall,Helmut K. Seitz,Patrice Couzigou,Xavier Parés +21 more
TL;DR: The ADH 2*2 allele decreases the risk for alcoholism, whereas the ADH2*2 and ADH3*1 alleles are found to be associated in the European population.
Journal ArticleDOI
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle.
Marion Schmidt,Wilhelm Haas,Bernat Crosas,Patricia G. Santamaría,Patricia G. Santamaría,Steven P. Gygi,Thomas Walz,Daniel Finley +7 more
TL;DR: This work describes an alternative proteasome activator from Saccharomyces cerevisiae, Blm10, which is found predominantly within hybrid Blm 10–CP–RP complexes, representing a distinct pool of mature proteasomes.