Bernhard Kubanek

TL;DR: It is suggested that the dissociation between erythroid response and changes in the CFU reflect a secondary effect of hypoxia not directly related to the erythropoietin-induced increase in red cell production.

TL;DR: It is concluded that the stem cell participates in the physiologic response to erythropoietin but without depletion of this compartment and the splenic CFU began to increase within 24 hours after the beginning of treatment and reached levels of 5-fold those of controls between days 8 and 16.

TL;DR: Pluripotential cells derived from fetal liver had a lower plating efficiency than adult marrow cells, but estimates of the generation time derived from the growth curve are significantly shorter and may account for the earlier erythroid population.

TL;DR: Findings might best be explained by a migration of stem cells during the post-hypoxic interval, which decreased during hypoxia and rose gradually there-after following, rather than preceeding, the increase in bone marrow CFU’s.

TL;DR: The data reported herein suggest that the differences in erythroid regeneration evoked by transplants of fetal liver, neonatal marrow or adult marrow, are not solely attributed to the degree of proliferation in the pluripotential stem cell compartment, and may suggest a shorter doubling time for cells comprising the fetal and newborn committed erythyroid compartments.