Showing papers in "Blood in 1968"

TL;DR: The recommended schedule of treatment for ara-C based on data is, therefore, daily infusions of 100 or 50 mg./m.2 in one hour for approximately 3 to 6 weeks followed by maintenance therapy of once weekly subcutaneous injection of 30 mg./ m.2 of aRA-C.

TL;DR: The change in platelet surface contour after exposure to ADP is not due to a direct modification of the cell wall by ADP, but to a contractile wave which ADP indirectly triggers in the substance of the cells.

TL;DR: Diminished concentrations of hemopexin were found only when the concentrations of haptoglobin were decreased; the former were not in all instances lowered to the same extent as the haPToglobin levels.

TL;DR: The nucleus of this Sezary cell was strikingly irregular, indented, lobulated, and serpentine, often narrowed to a single row of nuclear particles, and the cytoplasm exhibited no abnormalities.

TL;DR: Human monocytes isolated from peripheral blood phagocytized polystyrene particles, Escherichia coli, Staphylococcus aureus, Candida albicans, Cryptococcus neoformans, and red cells coated with IgG antibody in vitro were studied for ingestion of fungi and bacteria.

TL;DR: The findings of von Willebrand's syndrome disappeared following corticosteroid therapy and did not return after cessation of therapy, leading to the belief that the bleeding syndrome was acquired rather than inherited.

TL;DR: The development of other chromosomal abnormalities in Ph1 positive patients presaged the terminal stage of the disease.

TL;DR: The red cells of four subjects with this disorder and of some family members have been investigated and the G-6-PD of the first subject was different than any previously described mutant enzyme and was named Albuquerque; the second patient showed the presence of a new type of variant, which has been named Duarte.

TL;DR: A new congenital hemolytic anemia not characterized by spherocytosis has been defined as due to a deficiency in another glycolytic enzyme, glucosephosphate isomerase, the catalyst specific for the second step of the Embden-Meyerhof glycoleytic pathway.

TL;DR: Studies in subjects made anemic by bleeding demonstrated an inverse relationship between hematocrit and the log of erythropoietin excretion, and patients with hypoxia-induced erythrocytosis had increased levels of urinary eries when their hematOCrit was reduced to normal levels by phlebotomy.

TL;DR: It is suggested that hemolytic anemia may occur in patients with vitamin E deficiency (i.e., with steatorrhea) if oxidant drugs capable of generating H2O2 and oxidizing membrane thiols are administered.

TL;DR: Of 82 patients with plasma cell myeloma treated with melphalan, 40 (49 per cent) were improved in clinical status and in a direct manifestation of disease, thus supporting the usefulness of these parameters in confirming clinical response.

TL;DR: Characterizing the onset of the terminal phase of chronic granulocytic leukemia permits an opportunity to introduce in sufficient time new therapeutic agents for the treatment of a phase of a disease which heretofore has been refractory to conventional therapy.

TL;DR: Plasmas from two of twenty-seven families with hemophilia A have a cross-reacting material which inactivates an anticoagulant to AHF.

TL;DR: Sera from ten of sixteen patients with known Gaucher’s disease were found to have immunoglobulin abnormalities, and four patients had "monoclonal" IgG type K protein increases.

TL;DR: In Polypliidy and Maturation of Rat Megakaryocytes, by O’Dell and Jackson (Blood 32: No. 1, July, 102-110, 1968), there appeared two typographical errors.

TL;DR: The findings suggested that thrombocytopenia affected megakaryocytopoiesis at the precursor cell level with resultant macrocytosis in rats.

TL;DR: Increased production of platelets was apparent during recovery from acute thrombocytopenia in rats and there was acceleration of maturation of megakaryocytes as determined from the pattern of labeling with 3HTdR.

TL;DR: Ultrastructural cytochemical observations revealed peroxidase reactivity in primary (azurophil) granules, but not in secondary (specific)granules, of rabbit and human polymorphonuclear leukocytes.

TL;DR: Metabolic concomitants of phagocytosis, including enhanced incorporation of uridine into RNA, stimulation of glucose oxidation and degranulation and loss of lysosomal enzymes were similar in neutrophils and eosinophils.

TL;DR: An abnormal hemoglobin, termed hemoglobin Kempsey, was found in association with erythrocytosis in ten members of an Australian family and identified a single amino acid substitution, β99Asp→Asn.

TL;DR: It is suggested that the dissociation between erythroid response and changes in the CFU reflect a secondary effect of hypoxia not directly related to the erythropoietin-induced increase in red cell production.

TL;DR: Marrow cavities permanently aplastic after irradiation were mechanically disrupted and locally injected with bone marrow obtained from an opposite leg and Hemopoietic bone marrow regenerated with restoration of normal parenchymal and sinusoidal architecture.

TL;DR: A closed continuous flow centrifuge was used to separate and collect large quantities of buffy coat cells from the dog and machine-separated lymphocytes responded normally to phytohemagglutinin.

TL;DR: A method for the separation of leukocyte from peripheral blood, using flotation over Ficoll, is described, and the leukocytes isolated show good preservation of their morphologic integrity, are motile and capable of phagocytosis.

TL;DR: Intravenously administered H3TdR was used to study peripheral blood leukocyte kinetics of patients with CLL in relapse and one in partial remission to support the concept that there is a progressive widespread accumulation of long-lived lymphocytes in CLL often leading to splenic pooling and, in some cases, hypersplenism.

TL;DR: Observations suggest that ADP aggregation and clot retraction are independent phenomena.

TL;DR: The effect of several simple sugars on the mitogenic and binding properties of PHA has been investigated and the binding of I131 labeled PHA to cells was decreased by NAGAL or EDTA.

TL;DR: The relationship between the morphology of human erythropoietic cells and their position in interphase has been studied in this article, showing that a significant increase in nuclear size occurs as a cell moves through its cell cycle.