Regulation of Erythropoiesis: XXIII. Dissociation between Stem Cell and Erythroid Response to Hypoxia
Bernhard Kubanek,Bernhard Kubanek,Luigi Ferrari,Luigi Ferrari,William S. Tyler,William S. Tyler,Donald Howard,Donald Howard,Susan Jay,Susan Jay,Frederick Stohlman +10 more
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TLDR
It is suggested that the dissociation between erythroid response and changes in the CFU reflect a secondary effect of hypoxia not directly related to the erythropoietin-induced increase in red cell production.About:
This article is published in Blood.The article was published on 1968-10-01 and is currently open access. It has received 92 citations till now. The article focuses on the topics: Erythropoiesis & Red Cell.read more
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Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo
Jingping Hu,Jingping Hu,Jing Liu,Jing Liu,Fumin Xue,Gregory R. Halverson,Marion E. Reid,Anqi Guo,Lixiang Chen,Azra Raza,Naomi Galili,Julie Jaffray,Joseph M. Lane,Joel Anne Chasis,Naomi Taylor,Narla Mohandas,Xiuli An,Xiuli An +17 more
TL;DR: By examining the dynamic changes of expression of membrane proteins during in vitro human terminal erythroid differentiation, band 3 and α4 integrin are identified as optimal surface markers for isolating 5 morphologically distinct populations at successive developmental stages and should facilitate a comprehensive cellular and molecular characterization of each specific developmental stage of human erythroblasts.
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Structure and Function of Bone Marrow Hemopoiesis: Mechanisms of Response to Ionizing Radiation Exposure
TL;DR: The purpose of this presentation is to review the unique structure and function of bone marrow anchored hematopoiesis in their significance for its response mechanisms to an exposure to ionizing radiation.
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The erythropoietin-hematocrit relationship in normal and polycythemic man: implications of marrow regulation.
TL;DR: Studies in subjects made anemic by bleeding demonstrated an inverse relationship between hematocrit and the log of erythropoietin excretion, and patients with hypoxia-induced erythrocytosis had increased levels of urinary eries when their hematOCrit was reduced to normal levels by phlebotomy.
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Embryonic Red Blood Cell Formation
TL;DR: The purpose of this note is to point out certain strikingly similar features of erythropoiesis in the embryos of man, mouse and chicken and in the metamorphosing larva of the bullfrog, features which might well be more widespread among animals.
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Postnatal changes in erythropoietin levels in untransfused premature infants
TL;DR: During the second postnatal month, preterm infants had essentially the same erythropoietin values as in adults despite a mean hemoglobin concentration that averaged less than two thirds the adult value, which may explain why hemoglobin declines to such low values at 2 months of age.